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Total 959151 Results
| Label | Description | ILX | Version | Created CID | Modified Time | ||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| Loxapine | An antipsychotic agent used in schizophrenia. (PubChem) Pharmacology: Loxapine, a dibenzoxazepine compound, represents a subclass of tricyclic antipsychotic agents, chemically distinct from the thioxanthenes, butyrophenones, and phenothiazines. Pharmacologically, Loxapine is a tranquilizer for which the exact mode of action has not been established. Mechanism of action: Loxapine is a dopamine antagonist, and also a serotonin 5-HT2 blocker. The exact mode of action of Loxapine has not been established, however changes in the level of excitability of subcortical inhibitory areas have been observed in several animal species in association with such manifestations of tranquilization as calming effects and suppression of aggressive behavior. Drug type: Approved. Small Molecule. Drug category: Antipsychotic Agents. Antipsychotics. Dopamine Antagonists | ILX:0106380 | 3 | FDI Lab - SciCrunch.org | 06/18/2018 | FDI Lab - SciCrunch.org | term | 12/08/2016 | 0 | NeuroLex | NeuroLex |
| LP neuron | Period-expressing neuron located in a cluster of 3-4 cells in the lateral central brain, medial to the LNd cluster and near the posterior of the brain (Shafer et al., 2006, Helfrich-Forster, 2005). | ILX:0106381 | 3 | FDI Lab - SciCrunch.org | 06/18/2018 | FDI Lab - SciCrunch.org | term | 12/08/2016 | 0 | NeuroLex | NeuroLex |
| LP1 neuron | Serotonergic neuron whose cell body is located in one of 2 (bilateral) clusters: in the larva these clusters occupy a mid-lateral position at the optic lobe margin and have axons that join a midline-crossing tract, in the adult they are located in the cortex of the lateral protocerebrum, anterior to the optic tract and project their axons centrally into the midbrain. | ILX:0106382 | 3 | FDI Lab - SciCrunch.org | 06/18/2018 | FDI Lab - SciCrunch.org | term | 12/08/2016 | 0 | NeuroLex | NeuroLex |
| LP2 neuron | Serotonergic neuron whose cell bodies are located in 2 pairs of clusters (a and b) in the adult brain in the cortex of optic peduncle, adjacent to the medulla layer. These cells are born during metamorphosis. | ILX:0106383 | 3 | FDI Lab - SciCrunch.org | 06/18/2018 | FDI Lab - SciCrunch.org | term | 12/08/2016 | 0 | NeuroLex | NeuroLex |
| LPA1 receptor | ILX:0106384 | 3 | FDI Lab - SciCrunch.org | 06/18/2018 | FDI Lab - SciCrunch.org | term | 12/08/2016 | 0 | NeuroLex | NeuroLex | |
| LPA2 receptor | ILX:0106385 | 3 | FDI Lab - SciCrunch.org | 06/18/2018 | FDI Lab - SciCrunch.org | term | 12/08/2016 | 0 | NeuroLex | NeuroLex | |
| LPA3 receptor | ILX:0106386 | 3 | FDI Lab - SciCrunch.org | 06/18/2018 | FDI Lab - SciCrunch.org | term | 12/08/2016 | 0 | NeuroLex | NeuroLex | |
| LSD | ILX:0106387 | 3 | FDI Lab - SciCrunch.org | 06/18/2018 | FDI Lab - SciCrunch.org | term | 12/08/2016 | 0 | NeuroLex | NeuroLex | |
| Lubiprostone | Lubiprostone is a medication used in the management of idiopathic chronic constipation. It is a bicyclic fatty acid (prostaglandin E1 derivative) which acts by specifically activating ClC-2 chloride channels on the apical aspect of gastrointestinal epithelial cells, producing a chloride-rich fluid secretion. These secretions soften the stool, increase motility, and promote spontaneous bowel movements (SBM). Pharmacology: Chronic idiopathic constipation is generally defined by infrequent or difficult passage of stool. The signs and symptoms associated with chronic idiopathic constipation (i.e., abdominal pain or discomfort, bloating, straining, and hard or lumpy stools) may be the result of abnormal colonic motility that can delay the transit of intestinal contents and impede the evacuation of rectal contents. One approach to the treatment of chronic idiopathic constipation is the secretion of fluid into the abdominal lumen through the activation of chloride channels in the apical membrane of the gastrointestinal epithelium. Lubiprostone is a locally acting chloride channel activator that enhances a chloride-rich intestinal fluid secretion without altering sodium and potassium concentrations in the serum. Mechanism of action: Lubiprostone acts by specifically activating ClC-2, which is a normal constituent of the apical membrane of the human intestine, in a protein kinase Aindependent fashion. By increasing intestinal fluid secretion, lubiprostone increases motility in the intestine, thereby increasing the passage of stool and alleviating symptoms associated with chronic idiopathic constipation. Patch clamp cell studies in human cell lines have indicated that the majority of the beneficial biological activity of lubiprostone and its metabolites is observed only on the apical (luminal) portion of the gastrointestinal epithelium. Drug type: Approved. Investigational. Small Molecule. Drug category: Anti-constipation Agents | ILX:0106388 | 3 | FDI Lab - SciCrunch.org | 06/18/2018 | FDI Lab - SciCrunch.org | term | 12/08/2016 | 0 | NeuroLex | NeuroLex |
| Luer and Fitting | Used to build liquid or gas flow systems, including: start, stop, add, divide, and control the flow of liquid or gas using one-way and three-way stopcocks, manifolds, Y-connectors, injection sites, male and female luer clamps, check valves, slide clamps, roller clamps, and pinch clamps. | ILX:0106389 | 3 | FDI Lab - SciCrunch.org | 06/18/2018 | FDI Lab - SciCrunch.org | term | 12/08/2016 | 0 | NeuroLex | NeuroLex |
| Lumbar dorsal root ganglion | The group of nerve cell bodies located on the dorsal spinal roots within the vertebral column at the level of the lumbar vertebrae. | ILX:0106390 | 10 | FDI Lab - SciCrunch.org | 11/30/2020 | FDI Lab - SciCrunch.org | term | 12/08/2016 | 0 | NeuroLex | NeuroLex |
| Lumbar spinal cord | . | ILX:0106391 | 11 | FDI Lab - SciCrunch.org | 11/30/2020 | FDI Lab - SciCrunch.org | term | 12/08/2016 | 0 | NeuroLex | NeuroLex |
| Lumbar spinal cord central canal | Part of central canal lying within the lumbar spinal cord. It is continuous rostrally with the central canal of the thoracic spinal cord and caudally with the central canal of the sacral spinal cord. | ILX:0106392 | 9 | FDI Lab - SciCrunch.org | 06/23/2020 | FDI Lab - SciCrunch.org | term | 12/08/2016 | 0 | NeuroLex | NeuroLex |
| Lumbar spinal cord dorsal column | A subdivision of spinal cord dorsal column that is part of a lumbar spinal cord. | ILX:0106393 | 11 | FDI Lab - SciCrunch.org | 11/30/2020 | FDI Lab - SciCrunch.org | term | 12/08/2016 | 0 | NeuroLex | NeuroLex |
| Lumbar spinal cord dorsal horn | A dorsal horn of spinal cord that is part of a lumbar spinal cord. | ILX:0106394 | 7 | FDI Lab - SciCrunch.org | 11/30/2020 | FDI Lab - SciCrunch.org | term | 12/08/2016 | 0 | NeuroLex | NeuroLex |
| Lumbar spinal cord gray commissure | ILX:0106395 | 7 | FDI Lab - SciCrunch.org | 11/30/2020 | FDI Lab - SciCrunch.org | term | 12/08/2016 | 0 | NeuroLex | NeuroLex | |
| Lumbar spinal cord gray matter | ILX:0106396 | 6 | FDI Lab - SciCrunch.org | 11/30/2020 | FDI Lab - SciCrunch.org | term | 12/08/2016 | 0 | NeuroLex | NeuroLex | |
| Lumbar spinal cord lateral column | A subdivision of spinal cord lateral column that is part of a lumbar spinal cord. | ILX:0106397 | 6 | FDI Lab - SciCrunch.org | 11/30/2020 | FDI Lab - SciCrunch.org | term | 12/08/2016 | 0 | NeuroLex | NeuroLex |
| Lumbar spinal cord lateral horn | ILX:0106398 | 6 | FDI Lab - SciCrunch.org | 11/30/2020 | FDI Lab - SciCrunch.org | term | 12/08/2016 | 0 | NeuroLex | NeuroLex | |
| Lumbar spinal cord ventral column | A subdivision of spinal cord ventral column that is part of a lumbar spinal cord. | ILX:0106399 | 6 | FDI Lab - SciCrunch.org | 11/30/2020 | FDI Lab - SciCrunch.org | term | 12/08/2016 | 0 | NeuroLex | NeuroLex |
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