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Total 959151 Results
| Label | Description | ILX | Version | Created CID | Modified Time | ||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| Lisdexamfetamine | Lisdexamfetamine (L-lysine-d-amphetamine) is a prodrug of the psychostimulant d-amphetamine coupled with the essential amino acid L-lysine. It was developed so that the amphetamine psychostimulant is released and activated more slowly as the prodrug molecule is hydrolyzed consequently cleaving off the amino acid-during the first pass through the intestines and/or the liver. Amphetamines target the trace amine-associated receptor 1 (TAAR1). Amphetamine is also believed to exert its effects by binding to the monoamine transporters (the dopamine transporter or DAT) and increasing extracellular levels of the biogenic amines dopamine, norepinephrine (noradrenaline) and serotonin. Pharmacology: Lisdexamfetamine is a pro-drug of dextroamphetamine. It works primarily by inducing the release of the neurotransmitters dopamine and norepinephrine from their storage areas in nerve terminals. Both of these transmitters contribute to maintaining alertness, increasing focus, and sustaining thought, effort, and motivation. Mechanism of action: Lisdexamfetamine is a pro-drug of dextroamphetamine. Amphetamines are thought to block the reuptake of norepinephrine and dopamine into the presynaptic neuron and increase the release of these monoamines into the extraneuronal space. Norepinephrine and dopamine contribute to maintaining alertness, increasing focus, and sustaining thought, effort, and motivation. However, the exact therapeutic action in ADHD is not known. Drug type: Approved. Investigational. Small Molecule. Drug category: Central Nervous System Agents | ILX:0106300 | 3 | FDI Lab - SciCrunch.org | 06/18/2018 | FDI Lab - SciCrunch.org | term | 12/08/2016 | 0 | NeuroLex | NeuroLex |
| Lisinopril | One of the angiotensin-converting enzyme inhibitors (ACE inhibitors), orally active, that has been used in the treatment of hypertension and congestive heart failure. (PubChem) Pharmacology: Lisinopril, an angiotensin-converting enzyme (ACE) inhibitor, is used to treat hypertension, congestive heart failure (CHF), postmyocardial infarction, and diabetic nephropathy or retinopathy. Although it is the lysine ester of enalaprilat, the active form of the prodrug enalapril, lisinopril is active unchanged. Mechanism of action: Lisinopril competes with angiotensin I for its binding site on the angiotensin-converting enzyme (ACE), an enzyme which converts angiotensin I to angiotensin II. As angiotensin II is a vasoconstrictor and a negative feedback mediator for renin activity, lower angiotensin II plasma levels result in decreased blood pressure and increased plasma renin activity. Baroreceptor reflex mechanisms, stimulated by the fall in blood pressure, release kininase II, an enzyme identical to ACE that degrades bradykinin, a vasodilator. Drug type: Approved. Investigational. Small Molecule. Drug category: Angiotensin-converting Enzyme Inhibitors. Antihypertensive Agents. Cardiotonic Agents | ILX:0106301 | 3 | FDI Lab - SciCrunch.org | 06/18/2018 | FDI Lab - SciCrunch.org | term | 12/08/2016 | 0 | NeuroLex | NeuroLex |
| Lissauer's tract of medulla | Part of Lissauer's tract located in the medulla | ILX:0106302 | 12 | FDI Lab - SciCrunch.org | 01/17/2023 | FDI Lab - SciCrunch.org | term | 12/08/2016 | 0 | NeuroLex | troy sincomb |
| Lissauer's tract of spinal cord | White matter tract in spinal cord laying between the substantia gelatinosa and the surface of the spinal cord. | ILX:0106303 | 5 | FDI Lab - SciCrunch.org | 08/24/2018 | FDI Lab - SciCrunch.org | term | 12/08/2016 | 0 | NeuroLex | troy sincomb |
| Lissauers tract | ILX:0106304 | 5 | FDI Lab - SciCrunch.org | 10/08/2021 | SPARC SAWG | term | 12/08/2016 | 0 | NeuroLex | Maryann Martone | |
| Listserv | Documented communication of a listserv or discussion group (as an entity, as opposed to a single discussion thread which uses the value "discussion") that uses one of the listserv software as a medium (based on NLM definition, augmented by NIF). | ILX:0106305 | 4 | FDI Lab - SciCrunch.org | 08/24/2018 | FDI Lab - SciCrunch.org | term | 12/08/2016 | 0 | NeuroLex | troy sincomb |
| Listening span task | A task in which subjects must listen to a set of sentences and remember the last word in the sentence. The number of words that can be recalled is the "listening span." | ILX:0106306 | 5 | FDI Lab - SciCrunch.org | 09/07/2018 | FDI Lab - SciCrunch.org | term | 12/08/2016 | 0 | NeuroLex | troy sincomb |
| Lisuride | An ergot derivative that acts as an agonist at dopamine D2 receptors (dopamine agonists). It may also act as an antagonist at dopamine D1 receptors, and as an agonist at some serotonin receptors (serotonin agonists). (PubChem) Pharmacology: Not Available Mechanism of action: Lisuride is an anti-Parkinson drug chemically related to the dopaminergic ergoline Parkinson's drugs. Lisuride binds to the 5-HT(1A) and 5-HT(2A/2C) receptors. It is also thought to bind to the dopamine receptor and to act as a dopamine agonist. Evidence has also emerged that Lisuride also binds to the Histamine H1 receptor. Lisuride is also used to lower prolactin and, in low doses, to prevent migraine attacks. Drug type: Approved. Small Molecule. Drug category: Antidyskinetics. Antiparkinson Agents. Dopamine Agonists. Serotonin Agonists | ILX:0106307 | 4 | FDI Lab - SciCrunch.org | 08/24/2018 | FDI Lab - SciCrunch.org | term | 12/08/2016 | 0 | NeuroLex | troy sincomb |
| Literature corpus | The scientific literature, language processing, reference information, and documentation. | ILX:0106308 | 5 | FDI Lab - SciCrunch.org | 08/01/2022 | FDI Lab - SciCrunch.org | term | 12/08/2016 | 0 | NeuroLex | NeuroLex |
| Little brown bat | ILX:0106309 | 5 | FDI Lab - SciCrunch.org | 06/18/2018 | FDI Lab - SciCrunch.org | term | 12/08/2016 | 0 | NeuroLex | NeuroLex | |
| Living arrangement assessment | An assessment of the manner in which an individual habitates, with particular reference to whom living space is shared (e.g., spouse, children, significant other, friend, other family member(s)). | ILX:0106310 | 3 | FDI Lab - SciCrunch.org | 06/18/2018 | FDI Lab - SciCrunch.org | term | 12/08/2016 | 0 | NeuroLex | NeuroLex |
| LLN | Local interneuron of the adult antennal lobe, from the lateral AL neuroblast lineage. | ILX:0106311 | 3 | FDI Lab - SciCrunch.org | 06/18/2018 | FDI Lab - SciCrunch.org | term | 12/08/2016 | 0 | NeuroLex | NeuroLex |
| LN period neuron | Period (FBgn0003068) expressing neuron of the adult brain whose cell body is located in the cortical region between the medulla and the central brain neuropil. | ILX:0106312 | 3 | FDI Lab - SciCrunch.org | 06/18/2018 | FDI Lab - SciCrunch.org | term | 12/08/2016 | 0 | NeuroLex | NeuroLex |
| LNd neuron | Lateral period-expressing neuron (LN) whose cell body is located in the dorsal-most cluster of LNs. These neurons project axons to the dorsal protocerebrum. These projections overlap with those of the DN neurons and many project contralaterally through the dorsal fusion commissure. Some dendrites from these neurons follow a complicated, looping path from the rest and project to the accessory medulla. | ILX:0106313 | 3 | FDI Lab - SciCrunch.org | 06/18/2018 | FDI Lab - SciCrunch.org | term | 12/08/2016 | 0 | NeuroLex | NeuroLex |
| LNv neuron | Lateral period-expressing neuron (LN) whose cell body is located in the ventral cluster of LNs, at the level of the esophageal foramen (Helfrich-Forster, 1998). It has neurites associated with the accessory medulla (aMe) (Helfrich-Forster et al., 2007). The LN neuronal group are necessary and sufficient for generation of robust adult locomotor rhythms in the absence of environmental cues (Helfrich-Forster et al., 2007). | ILX:0106314 | 3 | FDI Lab - SciCrunch.org | 06/18/2018 | FDI Lab - SciCrunch.org | term | 12/08/2016 | 0 | NeuroLex | NeuroLex |
| Lobate | A shape quality in which the bearer has deeply undulating edges forming lobes. | ILX:0106315 | 3 | FDI Lab - SciCrunch.org | 06/18/2018 | FDI Lab - SciCrunch.org | term | 12/08/2016 | 0 | NeuroLex | NeuroLex |
| Lobe of cerebral cortex | Divisions of the cerebral cortex from gross anatomical observation based on the locations of major sulci and fissures in gyrencephalic animals, including both the gray matter and underlying white matter. From 4-6 lobes have been defined. | ILX:0106316 | 10 | FDI Lab - SciCrunch.org | 01/17/2023 | FDI Lab - SciCrunch.org | term | 12/08/2016 | 0 | NeuroLex | NeuroLex |
| Lobe parts of the cerebellar cortex | A major subdivision of the cerebellum: anterior, posterior and flocculonodular | ILX:0106317 | 10 | FDI Lab - SciCrunch.org | 06/23/2020 | FDI Lab - SciCrunch.org | term | 12/08/2016 | 0 | NeuroLex | NeuroLex |
| Lobed | Partly divided into a determinate number of regions. | ILX:0106318 | 3 | FDI Lab - SciCrunch.org | 06/18/2018 | FDI Lab - SciCrunch.org | term | 12/08/2016 | 0 | NeuroLex | NeuroLex |
| Lobster | ILX:0106319 | 3 | FDI Lab - SciCrunch.org | 06/18/2018 | FDI Lab - SciCrunch.org | term | 12/08/2016 | 0 | NeuroLex | NeuroLex |
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