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Total 959151 Results
| Label | Description | ILX | Version | Created CID | Modified Time | ||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| Cistern of lamina terminalis | ILX:0102201 | 10 | FDI Lab - SciCrunch.org | 06/23/2020 | FDI Lab - SciCrunch.org | term | 12/08/2016 | 0 | NeuroLex | NeuroLex | |
| Citalopram | A furancarbonitrile that is one of the serotonin uptake inhibitors used as an antidepressant. The drug is also effective in reducing ethanol uptake in alcoholics and is used in depressed patients who also suffer from tardive dyskinesia in preference to tricyclic antidepressants, which aggravate this condition. (PubChem) Pharmacology: Citalopram is one of a class of antidepressants known as selective serotonin reuptake inhibitors (SSRIs). It is used to treat the depression associated with mood disorders. It is also used on occassion in the treatment of body dysmorphic disorder and anxiety. The antidepressant, antiobsessive-compulsive, and antibulimic actions of Citalopram are presumed to be linked to its inhibition of CNS neuronal uptake of serotonin. In vitro studies show that Citalopram is a potent and selective inhibitor of neuronal serotonin reuptake and has only very weak effects on norepinephrine and dopamine neuronal reuptake. Citalopram has no significant affinity for adrenergic (alpha1, alpha2, beta), cholinergic, GABA, dopaminergic, histaminergic, serotonergic (5HT1A, 5HT1B, 5HT2), or benzodiazepine receptors; antagonism of such receptors has been hypothesized to be associated with various anticholinergic, sedative, and cardiovascular effects for other psychotropic drugs. The chronic administration of Citalopram was found to downregulate brain norepinephrine receptors, as has been observed with other drugs effective in the treatment of major depressive disorder. Citalopram does not inhibit monoamine oxidase. Mechanism of action: The antidepressant, antiobsessive-compulsive, and antibulimic actions of Citalopram are presumed to be linked to its inhibition of CNS neuronal uptake of serotonin. Citalopram blocks the reuptake of serotonin at the serotonin reuptake pump of the neuronal membrane, enhancing the actions of serotonin on 5HT1A autoreceptors. SSRIs bind with significantly less affinity to histamine, acetylcholine, and norepinephrine receptors than tricyclic antidepressant drugs. Drug type: Approved. Small Molecule. Drug category: Antidepressants. Antidepressive Agents, Second-Generation. Selective Serotonin Reuptake Inhibitors (SSRIs). Serotonin Uptake Inhibitors | ILX:0102202 | 3 | FDI Lab - SciCrunch.org | 06/18/2018 | FDI Lab - SciCrunch.org | term | 12/08/2016 | 0 | NeuroLex | NeuroLex |
| Citation record | ILX:0102203 | 3 | FDI Lab - SciCrunch.org | 06/18/2018 | FDI Lab - SciCrunch.org | term | 12/08/2016 | 0 | NeuroLex | NeuroLex | |
| Citation record element | Those elements defined as a part of the PubMed DTD and used by many literature citation databases | ILX:0102204 | 3 | FDI Lab - SciCrunch.org | 06/18/2018 | FDI Lab - SciCrunch.org | term | 12/08/2016 | 0 | NeuroLex | NeuroLex |
| CIVM postnatal rat brain atlas parcellation scheme | Parcellation scheme for the CIVM postnatal rat brain atlas, designed as a developmental neuro-ontology for tracking regional changes in MR biomarkers throughout postnatal neurodevelopment. | ILX:0102205 | 3 | FDI Lab - SciCrunch.org | 06/18/2018 | FDI Lab - SciCrunch.org | term | 12/08/2016 | 0 | NeuroLex | NeuroLex |
| CIVM postnatal rat brain atlas parcellation scheme region | Brain regions defined in the CIVM postnatal rat brain atlas parcellation scheme and criteria for their identification in MRI images | ILX:0102206 | 3 | FDI Lab - SciCrunch.org | 06/18/2018 | FDI Lab - SciCrunch.org | term | 12/08/2016 | 0 | NeuroLex | NeuroLex |
| Cladodromous | A shape inhering in a bearer by virtue of having secondary branches freely branching toward the margin. | ILX:0102207 | 3 | FDI Lab - SciCrunch.org | 06/18/2018 | FDI Lab - SciCrunch.org | term | 12/08/2016 | 0 | NeuroLex | NeuroLex |
| Cladribine | An antineoplastic agent used in the treatment of lymphoproliferative diseases including hairy-cell leukemia. (PubChem) Pharmacology: Cladribine is a synthetic antineoplastic agent with immunosuppressive effects. Cladribine is one of a group of chemotherapy drugs known as the anti-metabolites.Anti-metabolites stop cells making and repairing DNA. Cancer cells need to make and repair DNA in order to grow and multiply. Mechanism of action: Cladribine is structurally related to fludarabine and pentostatin but has a different mechanism of action. It is phosphorylated to its corresponding nucleotide CdATP, which accumulates and is incorporated into the DNA of cells such as lymphocytes. High levels of CdATP lead to DNA strand breaks, inhibition of DNA synthesis, and cell death. Unlike other antimetabolite drugs, cladribine has cytotoxic effects on resting as well as proliferating lymphocytes. However, it does cause cells to accumulate at the G1/S phase junction, suggesting that cytotoxicity is associated with events critical to cell entry into S phase. It also binds purine nucleoside phosphorylase (PNP), however no relationship between this binding and a mechanism of action has been established. Drug type: Approved. Investigational. Small Molecule. Drug category: Antineoplastic Agents. Immunosuppressive Agents | ILX:0102208 | 3 | FDI Lab - SciCrunch.org | 06/18/2018 | FDI Lab - SciCrunch.org | term | 12/08/2016 | 0 | NeuroLex | NeuroLex |
| Clarithromycin | A semisynthetic macrolide antibiotic derived from erythromycin that is active against a variety of microorganisms. It can inhibit protein synthesis in bacteria by reversibly binding to the 50S ribosomal subunits. This inhibits the translocation of aminoacyl transfer-RNA and prevents peptide chain elongation. (PubChem) Pharmacology: Clarithromycin, a macrolide antibiotic similar to erythromycin and azithromycin, is effective against Mycobacterium avium complex (MAC) and is used for the treatment of Helicobacter pylori-associated peptic ulcer disease, community-acquired pneumonia, sinusitis, and chronic bronchitis. Clarithromycin is also used to treat respiratory tract, sexually transmitted, otitis media, and AIDS-related infections. Mechanism of action: Clarithromycin is first metabolized to 14-OH clarithromycin. Like other macrolides, it then binds to the 50 S subunit of the 70 S ribosome of the bacteria, blocking RNA-mediated bacterial protein synthesis. Clarithromycin also inhibits the hepatic microsomal CYP3A4 isoenzyme and P-glycoprotein, an energy-dependent drug efflux pump. Drug type: Approved. Small Molecule. Drug category: Anti-Bacterial Agents. Macrolides. Other Macrolides. Protein Synthesis Inhibitors | ILX:0102209 | 3 | FDI Lab - SciCrunch.org | 06/18/2018 | FDI Lab - SciCrunch.org | term | 12/08/2016 | 0 | NeuroLex | NeuroLex |
| Clarity | A method for the transformation of intact tissue into a nanoporous hydrogel-hybridized form (crosslinked to a three-dimensional network of hydrophilic polymers) that is fully assembled but optically transparent andmacromolecule-permeable. | ILX:0102210 | 3 | FDI Lab - SciCrunch.org | 06/18/2018 | FDI Lab - SciCrunch.org | term | 12/08/2016 | 0 | NeuroLex | NeuroLex |
| Clark WELeG 1951 Parcellation scheme | Parcellations or definitions of nervous system structures from Clark WELeG (1951): Central nervous system. In Cunningham's Text-Book of Anatomy, 9th edn, ed Brash JC (Oxford University Press, London), pp 835-1008. | ILX:0102211 | 5 | FDI Lab - SciCrunch.org | 08/24/2018 | FDI Lab - SciCrunch.org | term | 12/08/2016 | 0 | NeuroLex | troy sincomb |
| Clark WELeG 1951 Parcellation scheme region | Nervous system structure definitions from Clark WELeG (1951): Central nervous system. In Cunningham's Text-Book of Anatomy, 9th edn, ed Brash JC (Oxford University Press, London), pp 835-1008. | ILX:0102212 | 5 | FDI Lab - SciCrunch.org | 08/24/2018 | FDI Lab - SciCrunch.org | term | 12/08/2016 | 0 | NeuroLex | troy sincomb |
| Clarke's Nucleus | A rounded collection of cells locat4ed on the medial surface of the base of the posterior horn. Considered by many to be a part of the posterior horn. Two column-shaped nuclear masses formed by large cells. Clarke's nuclei are located in the regions dorsolateral to the central canal in the thoratic and upper lumbar segments. | ILX:0102213 | 17 | FDI Lab - SciCrunch.org | 03/11/2021 | FDI Lab - SciCrunch.org | term | 12/08/2016 | 0 | NeuroLex | troy sincomb |
| Class 1 small leucine-rich proteoglycan | A protein with a core domain composition consisting of eight to ten tandem leucine-rich repeat sequences that are flanked at either end by cysteine rich disulfide loops. [PMID:14562268] | ILX:0102214 | 7 | FDI Lab - SciCrunch.org | 10/24/2018 | FDI Lab - SciCrunch.org | term | 12/08/2016 | 0 | NeuroLex | troy sincomb |
| Class I dendritic arborizing neuron | A dendritic arborizing md sensory neuron with a long, dorsally directed primary dendrite which branches repeatedly along its length into antero-posteriorly oriented secondary dendrites. The dendrites are smooth and their branching pattern is relatively simple, with few side branches or varicosities. | ILX:0102215 | 3 | FDI Lab - SciCrunch.org | 06/18/2018 | FDI Lab - SciCrunch.org | term | 12/08/2016 | 0 | NeuroLex | NeuroLex |
| Class II dendritic arborizing neuron | A dendritic arborizing md sensory neuron with multiple long and sinuous dendrites. Their branching pattern is relatively symmetrical. Higher order branches are generally short stubs extending from the major trunks. | ILX:0102216 | 3 | FDI Lab - SciCrunch.org | 06/18/2018 | FDI Lab - SciCrunch.org | term | 12/08/2016 | 0 | NeuroLex | NeuroLex |
| Class III dendritic arborizing neuron | A dendritic arborizing md sensory neuron with long primary and secondary dendrites that have spiked protrusions along most of their length and at the ends of major branches. | ILX:0102217 | 3 | FDI Lab - SciCrunch.org | 06/18/2018 | FDI Lab - SciCrunch.org | term | 12/08/2016 | 0 | NeuroLex | NeuroLex |
| Class IV dendritic arborizing neuron | A dendritic arborizing md sensory neuron with a highly complex branching pattern that completely fills large regions of the body wall with its arbors. Each cell may have 800-900 terminal branches and more than 6 branch orders. | ILX:0102218 | 3 | FDI Lab - SciCrunch.org | 06/18/2018 | FDI Lab - SciCrunch.org | term | 12/08/2016 | 0 | NeuroLex | NeuroLex |
| Class project | A project conducted by students as part of a course or program of study. | ILX:0102219 | 3 | FDI Lab - SciCrunch.org | 06/18/2018 | FDI Lab - SciCrunch.org | term | 12/08/2016 | 0 | NeuroLex | NeuroLex |
| Classic Globoid Cell Leukodystrophy | ILX:0102220 | 3 | FDI Lab - SciCrunch.org | 06/18/2018 | FDI Lab - SciCrunch.org | term | 12/08/2016 | 0 | NeuroLex | NeuroLex |
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