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Total 422235 Results
| Label | Description | ILX | Version | Created CID | Modified Time | ||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| Gemtuzumab ozogamicin | Recombinant humanized IgG4, kappa antibody conjugated with a cytotoxic antitumor antibiotic, calicheamicin, isolated from fermentation of a bacterium, Micromonospora echinospora ssp. calichensis. The antibody portion of Mylotarg binds specifically to the CD33 antigen, The anti-CD33 hP67.6 antibody is produced by mammalian cell suspension culture using a myeloma NS0 cell line. Pharmacology: Used for the treatment of acute myeloid leukemia (AML), mylotarg binds to the CD33 antigen, which is expressed on the surface of leukemic cells in more than 80% of patients with AML. The CD33 antigen is not expressed on pluripotent hematopoietic stem cells or nonhematopoietic cells. This gives mylotarg the selectivity needed to target leukemic cells. Mechanism of action: Mylotarg is directed against the CD33 antigen expressed by hematopoietic cells. Binding of the anti-CD33 antibody portion of Mylotarg with the CD33 antigen results in the formation of a complex that is internalized. Upon internalization, the calicheamicin derivative is released inside the lysosomes of the myeloid cell. The released calicheamicin derivative binds to DNA in the minor groove resulting in DNA double strand breaks and cell death. Drug type: Approved. Biotech. Investigational. Drug category: Antineoplastic Agents | ILX:0104578 | 3 | FDI Lab - SciCrunch.org | 06/18/2018 | FDI Lab - SciCrunch.org | term | 12/08/2016 | 0 | NeuroLex | NeuroLex |
| Gender assessment | An assessment of gender, the assemblage of properties that distinguish people on the basis of their societal roles. (NCI) An assessment of gender, the socially-constructed identity of male or female. (MSH); An assessment of the sex of an organism.(BIRNLex). | ILX:0104579 | 3 | FDI Lab - SciCrunch.org | 06/18/2018 | FDI Lab - SciCrunch.org | term | 12/08/2016 | 0 | NeuroLex | NeuroLex |
| Gene | A region (or regions) that includes all of the sequence elements necessary to encode a functional transcript. A gene may include regulatory regions, transcribed regions and/or other functional sequence regions. | ILX:0104580 | 3 | FDI Lab - SciCrunch.org | 06/18/2018 | FDI Lab - SciCrunch.org | term | 12/08/2016 | 0 | NeuroLex | NeuroLex |
| Gene expression | The analysis of levels and patterns of synthesis of gene products (proteins and functional RNA) including interpretation in functional terms of gene expression data. | ILX:0104581 | 5 | FDI Lab - SciCrunch.org | 06/11/2021 | FDI Lab - SciCrunch.org | term | 12/08/2016 | 0 | NeuroLex | troy sincomb |
| Gene regulatory network model | ILX:0104582 | 3 | FDI Lab - SciCrunch.org | 06/18/2018 | FDI Lab - SciCrunch.org | term | 12/08/2016 | 0 | NeuroLex | NeuroLex | |
| Gene specific probe | ILX:0104583 | 3 | FDI Lab - SciCrunch.org | 06/18/2018 | FDI Lab - SciCrunch.org | term | 12/08/2016 | 0 | NeuroLex | NeuroLex | |
| General Linear Model | The general linear model (GLM) is a statistical linear model. It may be written as Y | ILX:0104584 | 3 | FDI Lab - SciCrunch.org | 06/18/2018 | FDI Lab - SciCrunch.org | term | 12/08/2016 | 0 | NeuroLex | NeuroLex |
| General Purpose Performed Procedure Step Status | Contains the state of the Performed Procedure Step. | ILX:0104585 | 4 | FDI Lab - SciCrunch.org | 06/18/2018 | FDI Lab - SciCrunch.org | term | 12/08/2016 | 0 | NeuroLex | NeuroLex |
| General Purpose Scheduled Procedure Step Priority | Scheduled Procedure Step priority. | ILX:0104586 | 4 | FDI Lab - SciCrunch.org | 06/18/2018 | FDI Lab - SciCrunch.org | term | 12/08/2016 | 0 | NeuroLex | NeuroLex |
| General Purpose Scheduled Procedure Step Status | A status that informs the operator and the worklist management system about the progress of the scheduled General Purpose procedure step. | ILX:0104587 | 4 | FDI Lab - SciCrunch.org | 06/18/2018 | FDI Lab - SciCrunch.org | term | 12/08/2016 | 0 | NeuroLex | NeuroLex |
| Generalized Anxiety Disorder | Excessive anxiety and worry occuring more days than not for a period of at least 6 months about a number of events or activities. Individual finds it difficult to control the worry. | ILX:0104588 | 3 | FDI Lab - SciCrunch.org | 06/18/2018 | FDI Lab - SciCrunch.org | term | 12/08/2016 | 0 | NeuroLex | NeuroLex |
| Generalized Convulsive Epilepsy | ILX:0104589 | 3 | FDI Lab - SciCrunch.org | 06/18/2018 | FDI Lab - SciCrunch.org | term | 12/08/2016 | 0 | NeuroLex | NeuroLex | |
| Generalized Epilepsy | Recurrent conditions characterized by epileptic seizures which arise diffusely and simultaneously from both hemispheres of the brain. Classification is generally based upon motor manifestations of the seizure (e.g., convulsive, nonconvulsive, akinetic, atonic, etc.) or etiology (e.g., idiopathic, cryptogenic, and symptomatic) (MeSH). | ILX:0104590 | 3 | FDI Lab - SciCrunch.org | 06/18/2018 | FDI Lab - SciCrunch.org | term | 12/08/2016 | 0 | NeuroLex | NeuroLex |
| Generalized Nonconvulsive Epilepsy | ILX:0104591 | 3 | FDI Lab - SciCrunch.org | 06/18/2018 | FDI Lab - SciCrunch.org | term | 12/08/2016 | 0 | NeuroLex | NeuroLex | |
| Generative memory activity | A behavioral activity which when expressed entails the generation and use of stored memories (BB:2008-03-13). | ILX:0104592 | 3 | FDI Lab - SciCrunch.org | 06/18/2018 | FDI Lab - SciCrunch.org | term | 12/08/2016 | 0 | NeuroLex | NeuroLex |
| Generative verbal activity | ILX:0104593 | 3 | FDI Lab - SciCrunch.org | 06/18/2018 | FDI Lab - SciCrunch.org | term | 12/08/2016 | 0 | NeuroLex | NeuroLex | |
| Generator potential | A graded response to a stimulus, or a graded depolarization induced in the terminal of a sensory receptor, which after achieving a certain level, is capable of producing an action potential in the afferent axon in the nearby sensory neuron | ILX:0104594 | 5 | FDI Lab - SciCrunch.org | 06/18/2018 | FDI Lab - SciCrunch.org | term | 12/08/2016 | 0 | NeuroLex | NeuroLex |
| Generically dependent continuant | b is a generically dependent continuant = Def. b is a continuant that g-depends_on one or more other entities. (axiom label in BFO2 Reference: [074-001]) | ILX:0104595 | 4 | FDI Lab - SciCrunch.org | 06/12/2021 | Kravitz | term | 12/08/2016 | 0 | NeuroLex | NeuroLex |
| Genetic assessment | A evaluative instrument collecting together either individual and/or pedigree related questions and/or data values all designed to evaluate the dependence of a particular trait or disorder on genetic variability. | ILX:0104596 | 3 | FDI Lab - SciCrunch.org | 06/18/2018 | FDI Lab - SciCrunch.org | term | 12/08/2016 | 0 | NeuroLex | NeuroLex |
| Genetically encoded calcium sensor | A molecule that can be used to measure calcium fluctuations in living cells based that is introduced via transfection, i.e., is genetically encoded. An early example of a genetically encoded calcium sensor is chameleon. | ILX:0104597 | 3 | FDI Lab - SciCrunch.org | 06/18/2018 | FDI Lab - SciCrunch.org | term | 12/08/2016 | 0 | NeuroLex | NeuroLex |
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