Integrated Models is a virtual database currently indexing computational models from: CellML, ModelDB, Open Source Brain, SimTK.
(last updated: Nov 23, 2022)
Data or Model ModelsDatabase | Model Name | Simulator Software | Model Type | Neurons | Neurotransmitters | Receptors | ||||
---|---|---|---|---|---|---|---|---|---|---|
ModelDB | Collection of simulated data from a thalamocortical network model (Glabska, Chintaluri, Wojcik 2017) | NEURON (web link to model), Python (web link to model) | Realistic Network | Thalamus geniculate nucleus/lateral principal GLU cell, Thalamus reticular nucleus GABA cell, Neocortex L5/6 pyramidal GLU cell, Neocortex L2/3 pyramidal GLU cell, Neocortex V1 L5B pyramidal pyramidal tract GLU cell | GabaA, AMPA, NMDA | I Na,p, I Na,t, I L high threshold, I T low threshold, I A, I K, I M, I h, I K,Ca, I Calcium, I A, slow | Activity Patterns, Bursting, Temporal Pattern Generation, Oscillations, Simplified Models, Epilepsy, Sleep, Methods, Spindles | "A major challenge in experimental data analysis is the validation of analytical methods in a fully controlled scenario where the justification of the interpretation can be made directly and not just by plausibility. ... One solution is to use simulations of realistic models to generate ground truth data. In neuroscience, creating such data requires plausible models of neural activity, access to high performance computers, expertise and time to prepare and run the simulations, and to process the output. To facilitate such validation tests of analytical methods we provide rich data sets including intracellular voltage traces, transmembrane currents, morphologies, and spike times. ... The data were generated using the largest publicly available multicompartmental model of thalamocortical network (Traub et al. 2005), with activity evoked by different thalamic stimuli." | Glabska, Helena [glabska@gmail.com [glabska at gmail.com], Chintaluri, Chaitanya [c.chintaluri at nencki.gov.pl] |
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