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Drug Related Gene Database: DRG

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Organism:C57BL/6J Mouse: Male, 8-12 weeks prior to the onset of the experiments Adult mouse (facet)

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Sharf et al., Biol Psychiatry. 2008	Fos FBJ osteosarcoma oncogene	Ventral tegmental area	SB-334867 vs. Saline	C57BL/6J Mouse: Male, 8-12 weeks prior to the onset of the experiments Adult mouse		immunohistochemistry	Chronic morphine	table:1, Cell counts for immunohistochemical quantification are indicated., TH and c-Fos double-labeling in the VTA and LC, c-Fos single-labeling in the NAc
Sharf et al., Biol Psychiatry. 2008	Th Tyrosine hydroxylase	Locus ceruleus	SB-334867 vs. Saline	C57BL/6J Mouse: Male, 8-12 weeks prior to the onset of the experiments Adult mouse		immunohistochemistry	Morphine withdrawal	table:1, Cell counts for immunohistochemical quantification are indicated., TH and c-Fos double-labeling in the VTA and LC, c-Fos single-labeling in the NAc
Sharf et al., Biol Psychiatry. 2008	Fos FBJ osteosarcoma oncogene	Core of nucleus accumbens	SB-334867 vs. Saline	C57BL/6J Mouse: Male, 8-12 weeks prior to the onset of the experiments Adult mouse	No change in staining	immunohistochemistry	Morphine withdrawal	table:1, Cell counts for immunohistochemical quantification are indicated., TH and c-Fos double-labeling in the VTA and LC, c-Fos single-labeling in the NAc
Sharf et al., Biol Psychiatry. 2008	Hcrt Hypocretin	Lateral region of the lateral hypothalamus	Naloxone vs. Saline	C57BL/6J Mouse: Male, 8-12 weeks prior to the onset of the experiments Adult mouse		immunohistochemistry	Chronic morphine + SB-334867	table:1, Cell counts for immunohistochemical quantification are indicated., Orexin and c-Fos double-labeling in the LH
Sharf et al., Biol Psychiatry. 2008	Fos FBJ osteosarcoma oncogene	Lateral region of the lateral hypothalamus	SB-334867 vs. Saline	C57BL/6J Mouse: Male, 8-12 weeks prior to the onset of the experiments Adult mouse		immunohistochemistry	Morphine withdrawal	table:1, Cell counts for immunohistochemical quantification are indicated., Orexin and c-Fos double-labeling in the LH
Sharf et al., Biol Psychiatry. 2008	Th Tyrosine hydroxylase	Locus ceruleus	SB-334867 vs. Saline	C57BL/6J Mouse: Male, 8-12 weeks prior to the onset of the experiments Adult mouse	No change in staining	immunohistochemistry	Chronic morphine	table:1, Cell counts for immunohistochemical quantification are indicated., TH and c-Fos double-labeling in the VTA and LC, c-Fos single-labeling in the NAc
Sharf et al., Biol Psychiatry. 2008	Hcrt Hypocretin	Lateral region of the lateral hypothalamus	SB-334867 vs. Saline	C57BL/6J Mouse: Male, 8-12 weeks prior to the onset of the experiments Adult mouse		immunohistochemistry	Morphine withdrawal	table:1, Cell counts for immunohistochemical quantification are indicated., Orexin and c-Fos double-labeling in the LH
Sharf et al., Biol Psychiatry. 2008	Th Tyrosine hydroxylase	Lateral region of the lateral hypothalamus	SB-334867 vs. Saline	C57BL/6J Mouse: Male, 8-12 weeks prior to the onset of the experiments Adult mouse		immunohistochemistry	Chronic morphine	table:1, Cell counts for immunohistochemical quantification are indicated., Orexin and c-Fos double-labeling in the LH
Sharf et al., Biol Psychiatry. 2008	Th Tyrosine hydroxylase	Ventral tegmental area	Naloxone vs. Saline	C57BL/6J Mouse: Male, 8-12 weeks prior to the onset of the experiments Adult mouse	No change in staining	immunohistochemistry	Chronic morphine + SB-334867	table:1, Cell counts for immunohistochemical quantification are indicated., TH and c-Fos double-labeling in the VTA and LC, c-Fos single-labeling in the NAc
Sharf et al., Biol Psychiatry. 2008	Th Tyrosine hydroxylase	Ventral tegmental area	Naloxone vs. Saline	C57BL/6J Mouse: Male, 8-12 weeks prior to the onset of the experiments Adult mouse		immunohistochemistry	Chronic morphine + SB-334867	table:1, Cell counts for immunohistochemical quantification are indicated., TH and c-Fos double-labeling in the VTA and LC, c-Fos single-labeling in the NAc
Sharf et al., Biol Psychiatry. 2008	Th Tyrosine hydroxylase	Dorsomedial hypothamalus	Naloxone vs. Saline	C57BL/6J Mouse: Male, 8-12 weeks prior to the onset of the experiments Adult mouse	Increased staining	immunohistochemistry	Chronic morphine	table:1, Cell counts for immunohistochemical quantification are indicated., Orexin and c-Fos double-labeling in the LH
Sharf et al., Biol Psychiatry. 2008	Th Tyrosine hydroxylase	Dorsomedial hypothamalus	SB-334867 vs. Saline	C57BL/6J Mouse: Male, 8-12 weeks prior to the onset of the experiments Adult mouse		immunohistochemistry	Morphine withdrawal	table:1, Cell counts for immunohistochemical quantification are indicated., Orexin and c-Fos double-labeling in the LH
Sharf et al., Biol Psychiatry. 2008	Th Tyrosine hydroxylase	Locus ceruleus	Naloxone vs. Saline	C57BL/6J Mouse: Male, 8-12 weeks prior to the onset of the experiments Adult mouse	No change in staining	immunohistochemistry	Chronic morphine	table:1, Cell counts for immunohistochemical quantification are indicated., TH and c-Fos double-labeling in the VTA and LC, c-Fos single-labeling in the NAc
Sharf et al., Biol Psychiatry. 2008	Fos FBJ osteosarcoma oncogene	Ventral tegmental area	SB-334867 vs. Saline	C57BL/6J Mouse: Male, 8-12 weeks prior to the onset of the experiments Adult mouse	No change in staining	immunohistochemistry	Morphine withdrawal	table:1, Cell counts for immunohistochemical quantification are indicated., TH and c-Fos double-labeling in the VTA and LC, c-Fos single-labeling in the NAc
Sharf et al., Biol Psychiatry. 2008	Fos FBJ osteosarcoma oncogene	Shell of nucleus accumbens	Naloxone vs. Saline	C57BL/6J Mouse: Male, 8-12 weeks prior to the onset of the experiments Adult mouse	Increased staining	immunohistochemistry	Chronic morphine	table:1, Cell counts for immunohistochemical quantification are indicated., TH and c-Fos double-labeling in the VTA and LC, c-Fos single-labeling in the NAc
Sharf et al., Biol Psychiatry. 2008	Th Tyrosine hydroxylase	Lateral region of the lateral hypothalamus	Naloxone vs. Saline	C57BL/6J Mouse: Male, 8-12 weeks prior to the onset of the experiments Adult mouse	No change in staining	immunohistochemistry	Chronic morphine + SB-334867	table:1, Cell counts for immunohistochemical quantification are indicated., Orexin and c-Fos double-labeling in the LH
Sharf et al., Biol Psychiatry. 2008	Th Tyrosine hydroxylase	Dorsomedial hypothamalus	SB-334867 vs. Saline	C57BL/6J Mouse: Male, 8-12 weeks prior to the onset of the experiments Adult mouse		immunohistochemistry	Chronic morphine	table:1, Cell counts for immunohistochemical quantification are indicated., Orexin and c-Fos double-labeling in the LH
Sharf et al., Biol Psychiatry. 2008	Fos FBJ osteosarcoma oncogene	Core of nucleus accumbens	Naloxone vs. Saline	C57BL/6J Mouse: Male, 8-12 weeks prior to the onset of the experiments Adult mouse	Increased staining	immunohistochemistry	Chronic morphine	table:1, Cell counts for immunohistochemical quantification are indicated., TH and c-Fos double-labeling in the VTA and LC, c-Fos single-labeling in the NAc
Sharf et al., Biol Psychiatry. 2008	Fos FBJ osteosarcoma oncogene	Ventral tegmental area	Naloxone vs. Saline	C57BL/6J Mouse: Male, 8-12 weeks prior to the onset of the experiments Adult mouse		immunohistochemistry	Chronic morphine + SB-334867	table:1, Cell counts for immunohistochemical quantification are indicated., TH and c-Fos double-labeling in the VTA and LC, c-Fos single-labeling in the NAc
Sharf et al., Biol Psychiatry. 2008	Th Tyrosine hydroxylase	Ventral tegmental area	SB-334867 vs. Saline	C57BL/6J Mouse: Male, 8-12 weeks prior to the onset of the experiments Adult mouse	No change in staining	immunohistochemistry	Morphine withdrawal	table:1, Cell counts for immunohistochemical quantification are indicated., TH and c-Fos double-labeling in the VTA and LC, c-Fos single-labeling in the NAc
Sharf et al., Biol Psychiatry. 2008	Fos FBJ osteosarcoma oncogene	Locus ceruleus	Naloxone vs. Saline	C57BL/6J Mouse: Male, 8-12 weeks prior to the onset of the experiments Adult mouse		immunohistochemistry	Chronic morphine	table:1, Cell counts for immunohistochemical quantification are indicated., TH and c-Fos double-labeling in the VTA and LC, c-Fos single-labeling in the NAc
Sharf et al., Biol Psychiatry. 2008	Th Tyrosine hydroxylase	Locus ceruleus	Naloxone vs. Saline	C57BL/6J Mouse: Male, 8-12 weeks prior to the onset of the experiments Adult mouse	No change in staining	immunohistochemistry	Chronic morphine	table:1, Cell counts for immunohistochemical quantification are indicated., TH and c-Fos double-labeling in the VTA and LC, c-Fos single-labeling in the NAc
Sharf et al., Biol Psychiatry. 2008	Th Tyrosine hydroxylase	Ventral tegmental area	Naloxone vs. Saline	C57BL/6J Mouse: Male, 8-12 weeks prior to the onset of the experiments Adult mouse		immunohistochemistry	Chronic morphine	table:1, Cell counts for immunohistochemical quantification are indicated., TH and c-Fos double-labeling in the VTA and LC, c-Fos single-labeling in the NAc
Sharf et al., Biol Psychiatry. 2008	Fos FBJ osteosarcoma oncogene	Locus ceruleus	Naloxone vs. Saline	C57BL/6J Mouse: Male, 8-12 weeks prior to the onset of the experiments Adult mouse		immunohistochemistry	Chronic morphine + SB-334867	table:1, Cell counts for immunohistochemical quantification are indicated., TH and c-Fos double-labeling in the VTA and LC, c-Fos single-labeling in the NAc
Sharf et al., Biol Psychiatry. 2008	Th Tyrosine hydroxylase	Perifornical area	SB-334867 vs. Saline	C57BL/6J Mouse: Male, 8-12 weeks prior to the onset of the experiments Adult mouse		immunohistochemistry	Chronic morphine	table:1, Cell counts for immunohistochemical quantification are indicated., Orexin and c-Fos double-labeling in the LH
Sharf et al., Biol Psychiatry. 2008	Fos FBJ osteosarcoma oncogene	Perifornical area	Naloxone vs. Saline	C57BL/6J Mouse: Male, 8-12 weeks prior to the onset of the experiments Adult mouse		immunohistochemistry	Chronic morphine + SB-334867	table:1, Cell counts for immunohistochemical quantification are indicated., Orexin and c-Fos double-labeling in the LH
Sharf et al., Biol Psychiatry. 2008	Fos FBJ osteosarcoma oncogene	Locus ceruleus	SB-334867 vs. Saline	C57BL/6J Mouse: Male, 8-12 weeks prior to the onset of the experiments Adult mouse		immunohistochemistry	Morphine withdrawal	table:1, Cell counts for immunohistochemical quantification are indicated., TH and c-Fos double-labeling in the VTA and LC, c-Fos single-labeling in the NAc
Sharf et al., Biol Psychiatry. 2008	Fos FBJ osteosarcoma oncogene	Perifornical area	SB-334867 vs. Saline	C57BL/6J Mouse: Male, 8-12 weeks prior to the onset of the experiments Adult mouse		immunohistochemistry	Morphine withdrawal	table:1, Cell counts for immunohistochemical quantification are indicated., Orexin and c-Fos double-labeling in the LH
Sharf et al., Biol Psychiatry. 2008	Th Tyrosine hydroxylase	Lateral region of the lateral hypothalamus	SB-334867 vs. Saline	C57BL/6J Mouse: Male, 8-12 weeks prior to the onset of the experiments Adult mouse		immunohistochemistry	Morphine withdrawal	table:1, Cell counts for immunohistochemical quantification are indicated., Orexin and c-Fos double-labeling in the LH
Sharf et al., Biol Psychiatry. 2008	Fos FBJ osteosarcoma oncogene	Dorsomedial hypothamalus	Naloxone vs. Saline	C57BL/6J Mouse: Male, 8-12 weeks prior to the onset of the experiments Adult mouse		immunohistochemistry	Chronic morphine	table:1, Cell counts for immunohistochemical quantification are indicated., Orexin and c-Fos double-labeling in the LH
Sharf et al., Biol Psychiatry. 2008	Fos FBJ osteosarcoma oncogene	Dorsomedial hypothamalus	SB-334867 vs. Saline	C57BL/6J Mouse: Male, 8-12 weeks prior to the onset of the experiments Adult mouse		immunohistochemistry	Morphine withdrawal	table:1, Cell counts for immunohistochemical quantification are indicated., Orexin and c-Fos double-labeling in the LH
Sharf et al., Biol Psychiatry. 2008	Th Tyrosine hydroxylase	Ventral tegmental area	Naloxone vs. Saline	C57BL/6J Mouse: Male, 8-12 weeks prior to the onset of the experiments Adult mouse	No change in staining	immunohistochemistry	Chronic morphine	table:1, Cell counts for immunohistochemical quantification are indicated., TH and c-Fos double-labeling in the VTA and LC, c-Fos single-labeling in the NAc
Sharf et al., Biol Psychiatry. 2008	Hcrt Hypocretin	Dorsomedial hypothamalus	Naloxone vs. Saline	C57BL/6J Mouse: Male, 8-12 weeks prior to the onset of the experiments Adult mouse		immunohistochemistry	Chronic morphine + SB-334867	table:1, Cell counts for immunohistochemical quantification are indicated., Orexin and c-Fos double-labeling in the LH
Sharf et al., Biol Psychiatry. 2008	Th Tyrosine hydroxylase	Perifornical area	Naloxone vs. Saline	C57BL/6J Mouse: Male, 8-12 weeks prior to the onset of the experiments Adult mouse	Increased staining	immunohistochemistry	Chronic morphine	table:1, Cell counts for immunohistochemical quantification are indicated., Orexin and c-Fos double-labeling in the LH
Sharf et al., Biol Psychiatry. 2008	Th Tyrosine hydroxylase	Locus ceruleus	SB-334867 vs. Saline	C57BL/6J Mouse: Male, 8-12 weeks prior to the onset of the experiments Adult mouse		immunohistochemistry	Chronic morphine	table:1, Cell counts for immunohistochemical quantification are indicated., TH and c-Fos double-labeling in the VTA and LC, c-Fos single-labeling in the NAc
Sharf et al., Biol Psychiatry. 2008	Fos FBJ osteosarcoma oncogene	Dorsomedial hypothamalus	SB-334867 vs. Saline	C57BL/6J Mouse: Male, 8-12 weeks prior to the onset of the experiments Adult mouse	No change in staining	immunohistochemistry	Chronic morphine	table:1, Cell counts for immunohistochemical quantification are indicated., Orexin and c-Fos double-labeling in the LH
Sharf et al., Biol Psychiatry. 2008	Hcrt Hypocretin	Lateral region of the lateral hypothalamus	SB-334867 vs. Saline	C57BL/6J Mouse: Male, 8-12 weeks prior to the onset of the experiments Adult mouse		immunohistochemistry	Chronic morphine	table:1, Cell counts for immunohistochemical quantification are indicated., Orexin and c-Fos double-labeling in the LH
Sharf et al., Biol Psychiatry. 2008	Fos FBJ osteosarcoma oncogene	Core of nucleus accumbens	SB-334867 vs. Saline	C57BL/6J Mouse: Male, 8-12 weeks prior to the onset of the experiments Adult mouse	No change in staining	immunohistochemistry	Chronic morphine	table:1, Cell counts for immunohistochemical quantification are indicated., TH and c-Fos double-labeling in the VTA and LC, c-Fos single-labeling in the NAc
Sharf et al., Biol Psychiatry. 2008	Th Tyrosine hydroxylase	Locus ceruleus	Naloxone vs. Saline	C57BL/6J Mouse: Male, 8-12 weeks prior to the onset of the experiments Adult mouse		immunohistochemistry	Chronic morphine + SB-334867	table:1, Cell counts for immunohistochemical quantification are indicated., TH and c-Fos double-labeling in the VTA and LC, c-Fos single-labeling in the NAc
Sharf et al., Biol Psychiatry. 2008	Fos FBJ osteosarcoma oncogene	Lateral region of the lateral hypothalamus	SB-334867 vs. Saline	C57BL/6J Mouse: Male, 8-12 weeks prior to the onset of the experiments Adult mouse	No change in staining	immunohistochemistry	Chronic morphine	table:1, Cell counts for immunohistochemical quantification are indicated., Orexin and c-Fos double-labeling in the LH
Sharf et al., Biol Psychiatry. 2008	Fos FBJ osteosarcoma oncogene	Lateral region of the lateral hypothalamus	Naloxone vs. Saline	C57BL/6J Mouse: Male, 8-12 weeks prior to the onset of the experiments Adult mouse		immunohistochemistry	Chronic morphine	table:1, Cell counts for immunohistochemical quantification are indicated., Orexin and c-Fos double-labeling in the LH
Sharf et al., Biol Psychiatry. 2008	Hcrt Hypocretin	Perifornical area	Naloxone vs. Saline	C57BL/6J Mouse: Male, 8-12 weeks prior to the onset of the experiments Adult mouse		immunohistochemistry	Chronic morphine	table:1, Cell counts for immunohistochemical quantification are indicated., Orexin and c-Fos double-labeling in the LH
Sharf et al., Biol Psychiatry. 2008	Th Tyrosine hydroxylase	Ventral tegmental area	SB-334867 vs. Saline	C57BL/6J Mouse: Male, 8-12 weeks prior to the onset of the experiments Adult mouse		immunohistochemistry	Chronic morphine	table:1, Cell counts for immunohistochemical quantification are indicated., TH and c-Fos double-labeling in the VTA and LC, c-Fos single-labeling in the NAc
Sharf et al., Biol Psychiatry. 2008	Hcrt Hypocretin	Lateral region of the lateral hypothalamus	Naloxone vs. Saline	C57BL/6J Mouse: Male, 8-12 weeks prior to the onset of the experiments Adult mouse		immunohistochemistry	Chronic morphine	table:1, Cell counts for immunohistochemical quantification are indicated., Orexin and c-Fos double-labeling in the LH
Sharf et al., Biol Psychiatry. 2008	Th Tyrosine hydroxylase	Dorsomedial hypothamalus	Naloxone vs. Saline	C57BL/6J Mouse: Male, 8-12 weeks prior to the onset of the experiments Adult mouse	Increased staining	immunohistochemistry	Chronic morphine + SB-334867	table:1, Cell counts for immunohistochemical quantification are indicated., Orexin and c-Fos double-labeling in the LH
Sharf et al., Biol Psychiatry. 2008	Hcrt Hypocretin	Perifornical area	Naloxone vs. Saline	C57BL/6J Mouse: Male, 8-12 weeks prior to the onset of the experiments Adult mouse		immunohistochemistry	Chronic morphine + SB-334867	table:1, Cell counts for immunohistochemical quantification are indicated., Orexin and c-Fos double-labeling in the LH
Sharf et al., Biol Psychiatry. 2008	Th Tyrosine hydroxylase	Ventral tegmental area	SB-334867 vs. Saline	C57BL/6J Mouse: Male, 8-12 weeks prior to the onset of the experiments Adult mouse		immunohistochemistry	Morphine withdrawal	table:1, Cell counts for immunohistochemical quantification are indicated., TH and c-Fos double-labeling in the VTA and LC, c-Fos single-labeling in the NAc
Sharf et al., Biol Psychiatry. 2008	Fos FBJ osteosarcoma oncogene	Shell of nucleus accumbens	SB-334867 vs. Saline	C57BL/6J Mouse: Male, 8-12 weeks prior to the onset of the experiments Adult mouse	Decreased staining	immunohistochemistry	Morphine withdrawal	table:1, Cell counts for immunohistochemical quantification are indicated., TH and c-Fos double-labeling in the VTA and LC, c-Fos single-labeling in the NAc
Sharf et al., Biol Psychiatry. 2008	Fos FBJ osteosarcoma oncogene	Shell of nucleus accumbens	SB-334867 vs. Saline	C57BL/6J Mouse: Male, 8-12 weeks prior to the onset of the experiments Adult mouse	No change in staining	immunohistochemistry	Chronic morphine	table:1, Cell counts for immunohistochemical quantification are indicated., TH and c-Fos double-labeling in the VTA and LC, c-Fos single-labeling in the NAc
Sharf et al., Biol Psychiatry. 2008	Th Tyrosine hydroxylase	Perifornical area	SB-334867 vs. Saline	C57BL/6J Mouse: Male, 8-12 weeks prior to the onset of the experiments Adult mouse	No change in staining	immunohistochemistry	Morphine withdrawal	table:1, Cell counts for immunohistochemical quantification are indicated., Orexin and c-Fos double-labeling in the LH

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