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Evidence of artemisinin partial resistance in North-western Tanzania: clinical and drug resistance markers study.

medRxiv : the preprint server for health sciences | 2024

Artemisinin-based combination therapies (ACTs) are the recommended antimalarial drugs for the treatment of uncomplicated malaria. The recent emergence of artemisinin partial resistance (ART-R) in Rwanda, Uganda and Eritrea is of great concern. In Tanzania, a nationwide molecular malaria surveillance in 2021 showed a high prevalence of the Kelch13 (K13) 561H mutation in Plasmodium falciparum from the north-western region, close to the border with Rwanda and Uganda. This study was conducted in 2022 to evaluate the efficacy of artemether-lumefantrine (AL) and artesunate-amodiaquine (ASAQ) for the treatment of uncomplicated falciparum malaria and to confirm the presence of ART-R in Tanzania.

Pubmed ID: 38352311 RIS Download

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Associated grants

  • Agency: NIAID NIH HHS, United States
    Id: K24 AI134990
  • Agency: NIAID NIH HHS, United States
    Id: R01 AI156267

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