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Publication

Mice with FVB-derived sequence on chromosome 17 succumb to disseminated virus infection due to aberrant NK cell and T cell responses.

iScience | 2023

Zoonotic arenavirus infections can result in viral hemorrhagic disease, characterized by platelet loss, petechia, and multi-organ injury. The mechanisms governing these outcomes are likely impacted by virus strain and infection dose, as well as an individual's genetic background and immune constitution. To better understand the processes leading to severe pathogenesis, we compared two strains of inbred mice, C57BL/6J (B6) and FVB/NJ (FVB), that have diametrically opposed outcomes during disseminated lymphocytic choriomeningitis virus (LCMV) infection. Infection caused minimal pathogenesis in B6 mice, whereas FVB mice developed acute hepatitis and perished due, in part, to aberrant NK cell and T cell responses. Susceptible mice showed an outgrowth of cytolytic CD4+ T cells and loss of Treg cells. B6 congenic mice with the FVB allele at a 25Mb locus on chromosome 17 recapitulated FVB pathogenesis upon infection. A locus containing a limited number of variants in immune-related genes greatly impacts survival during infection.

Pubmed ID: 38026197 RIS Download

Research resources used in this publication

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Antibodies used in this publication

Associated grants

  • Agency: NIAID NIH HHS, United States
    Id: R01 AI131685
  • Agency: NIAID NIH HHS, United States
    Id: R01 AI138337
  • Agency: NIAID NIH HHS, United States
    Id: R01 AI143894

Publication data is provided by the National Library of Medicine ® and PubMed ®. Data is retrieved from PubMed ® on a weekly schedule. For terms and conditions see the National Library of Medicine Terms and Conditions.

This is a list of tools and resources that we have found mentioned in this publication.

C57BL/6J (tool)

RRID:IMSR_JAX:000664

Mus musculus with name C57BL/6J from IMSR.

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C57BL/6J (tool)

RRID:IMSR_JAX:000664

Mus musculus with name C57BL/6J from IMSR.

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PE anti-T-bet (antibody)

RRID:AB_2200542

This monoclonal targets T-bet

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ROR gamma (t) Monoclonal Antibody (B2D), APC, eBioscience (antibody)

RRID:AB_2573254

This monoclonal targets ROR gamma (t)

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PE anti-mouse CD335 (NKp46) (antibody)

RRID:AB_2235755

This monoclonal targets CD335

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Brilliant Violet 421(TM) anti-mouse CD335 (NKp46) (antibody)

RRID:AB_10915472

This monoclonal targets CD335

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PerCP/Cyanine5.5 anti-mouse NK-1.1 (antibody)

RRID:AB_2132706

This monoclonal targets NK-1.1

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InVivoPlus anti-mouse NK1.1 (antibody)

RRID:AB_1107737

This monoclonal targets NK1.1

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PE anti-mouse NK-1.1 (antibody)

RRID:AB_313394

This monoclonal targets NK-1.1

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NK1.1 Monoclonal Antibody (PK136), Alexa Fluor™ 700, eBioscience (antibody)

RRID:AB_2574505

This monoclonal targets NK1.1

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InVivoPlus anti-mouse IL-4 (antibody)

RRID:AB_1107707

This monoclonal targets IL-4

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PE anti-mouse IL-17A (antibody)

RRID:AB_315464

This monoclonal targets IL-17A

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InVivoPlus mouse IgG2b isotype control (antibody)

RRID:AB_1107791

This isotype control targets Unknown Specificity

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InVivoPlus mouse IgG2a isotype control (antibody)

RRID:AB_1107771

This isotype control targets Unknown Specificity

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InVivoPlus anti-mouse IFNγ (antibody)

RRID:AB_1107694

This monoclonal targets IFNγ

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FITC anti-mouse IFN-gamma (antibody)

RRID:AB_315400

This monoclonal targets IFN-gamma

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APC anti-mouse IFN-gamma (antibody)

RRID:AB_315404

This monoclonal targets IFN-gamma

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Pacific Blue(TM) anti-human/mouse Granzyme B (antibody)

RRID:AB_2562195

This monoclonal targets Granzyme B

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FITC anti-human/mouse Granzyme B (antibody)

RRID:AB_2114575

This monoclonal targets Granzyme B

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Alexa Fluor(R) 647 anti-human/mouse Granzyme B (antibody)

RRID:AB_2294995

This monoclonal targets Granzyme B

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FOXP3 Monoclonal Antibody (FJK-16s), FITC, eBioscience (antibody)

RRID:AB_465243

This monoclonal targets FOXP3

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Caspase-3, Active Form (antibody)

RRID:AB_393750

This monoclonal targets Caspase-3

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PE/Cyanine7 anti-mouse CD186 (CXCR6) (antibody)

RRID:AB_2721669

This monoclonal targets CD186

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CD107b (LAMP-2) Monoclonal Antibody (eBioABL-93 (ABL-93)), FITC, eBioscience (antibody)

RRID:AB_657579

This monoclonal targets CD107b (LAMP-2)

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FITC anti-mouse CD107a (LAMP-1) (antibody)

RRID:AB_572006

This monoclonal targets CD107a

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APC anti-mouse CD49b (pan-NK cells) (antibody)

RRID:AB_313416

This monoclonal targets CD49b

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PE/Cyanine7 anti-mouse CD49a (antibody)

RRID:AB_2749931

This monoclonal targets CD49a

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FITC anti-mouse/human CD44 (antibody)

RRID:AB_312957

This monoclonal targets CD44

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Alexa Fluor(R) 700 anti-mouse/human CD44 (antibody)

RRID:AB_493713

This monoclonal targets CD44

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Ultra-LEAF(TM) Purified anti-mouse CD28 (antibody)

RRID:AB_2810330

This monoclonal targets CD28

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TruStain FcX(TM) (anti-mouse CD16/32) (antibody)

RRID:AB_1574975

This monoclonal targets CD16/32

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FITC anti-mouse/human CD11b (antibody)

RRID:AB_312788

This monoclonal targets CD11b

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PE anti-mouse/human CD11b (antibody)

RRID:AB_312790

This monoclonal targets CD11b

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anti-mouse CD8α (antibody)

RRID:AB_1125541

This monoclonal targets CD8α

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PE anti-mouse CD8a (antibody)

RRID:AB_312746

This monoclonal targets CD8a

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CD8 (antibody)

RRID:AB_2738474

This monoclonal targets CD8

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APC anti-mouse CD8a (antibody)

RRID:AB_312751

This monoclonal targets CD8a

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anti-mouse CD4 (antibody)

RRID:AB_1107636

This monoclonal targets CD4

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PE anti-mouse CD4 (antibody)

RRID:AB_312693

This monoclonal targets CD4

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FITC anti-mouse CD4 (antibody)

RRID:AB_312691

This monoclonal targets CD4

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Brilliant Violet 421(TM) anti-mouse CD4 (antibody)

RRID:AB_2562557

This monoclonal targets CD4

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CD4 (antibody)

RRID:AB_2738426

This monoclonal targets CD4

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APC anti-mouse CD4 (antibody)

RRID:AB_312719

This monoclonal targets CD4

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Alexa Fluor(R) 488 anti-mouse CD3 (antibody)

RRID:AB_389301

This monoclonal targets CD3

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Brilliant Violet 421(TM) anti-mouse CD3epsilon (antibody)

RRID:AB_10898314

This monoclonal targets CD3epsilon

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Ultra-LEAF(TM) Purified anti-mouse CD3epsilon (antibody)

RRID:AB_2616673

This monoclonal targets CD3epsilon

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