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Publication

Beta-spike-containing boosters induce robust and functional antibody responses to SARS-CoV-2 in macaques primed with distinct vaccines.

Cell reports | 2023

The reduced effectiveness of COVID-19 vaccines due to the emergence of variants of concern (VOCs) necessitated the use of vaccine boosters to bolster protection against disease. However, it remains unclear how boosting expands protective breadth when primary vaccine platforms are distinct and how boosters containing VOC spike(s) broaden humoral responses. Here, we report that boosters composed of recombinant spike antigens of ancestral (prototype) and Beta VOCs elicit a robust, pan-VOC, and multi-functional humoral response in non-human primates largely independent of the primary vaccine series platform. Interestingly, Beta-spike-containing boosters stimulate immunoglobulin A (IgA) with a greater breadth of recognition in protein-primed recipients when administered with adjuvant system 03 (AS03). Our results highlight the utility of a component-based booster strategy for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) for broad humoral recognition, independent of primary vaccine series. This is of high global health importance given the heterogeneity of primary vaccination platforms distributed.

Pubmed ID: 38007686 RIS Download

Research resources used in this publication

THP-1 (RRID:CVCL_0006) (cell line)

Additional research tools detected in this publication

None found

Antibodies used in this publication

Associated grants

Agency: NIAID NIH HHS, United States
Id: R01 AI080289
Agency: NIAID NIH HHS, United States
Id: R01 AI146785
Agency: NIAID NIH HHS, United States
Id: U19 AI142790
Agency: NCI NIH HHS, United States
Id: U01 CA260476
Agency: NIAID NIH HHS, United States
Id: P01 AI165072
Agency: NIAID NIH HHS, United States
Id: P01 AI165072
Agency: NIAID NIH HHS, United States
Id: U19 AI135995

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