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The differentiation fate of bone marrow mesenchymal stem cells (BMSCs) affects the progression of steroid-induced osteonecrosis of the femoral head (SONFH). We find that lncRNA DGCR5 encodes a 102-amino acid polypeptide, RIP (Rac1 inactivated peptide), which promotes the adipogenic differentiation of BMSCs and aggravates the progression of SONFH. RIP, instead of lncRNA DGCR5, binds to the N-terminal motif of RAC1, and inactivates the RAC1/PAK1 cascade, resulting in decreased Ser675 phosphorylation of β-catenin. Ultimately, the nuclear localization of β-catenin decreases, and the differentiation balance of BMSCs tilts toward the adipogenesis lineage. In the femoral head of rats, overexpression of RIP causes trabecular bone disorder and adipocyte accumulation, which can be rescued by overexpressing RAC1. This finding expands the regulatory role of lncRNAs in BMSCs and suggests RIP as a potential therapeutic target.
Pubmed ID: 37573506 RIS Download
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This polyclonal secondary targets IgG (H+L)
View all literature mentionsThis unknown targets IgG (H+L)
View all literature mentionsThis unknown targets Rabbit IgG
View all literature mentionsThis polyclonal targets Rabbit Phospho-Beta-Catenin (Ser675) Cy3
View all literature mentionsThis polyclonal targets IgG (H+L)
View all literature mentionsThis unknown targets Goat Anti-Mouse IgG (H+L) HRP
View all literature mentionsThis polyclonal targets Histone-H3
View all literature mentionsThis polyclonal targets FABP4
View all literature mentionsThis polyclonal secondary targets IgG (H+L)
View all literature mentionsThis polyclonal targets CEBPA
View all literature mentionsThis polyclonal targets PPAR Gamma
View all literature mentionsThis polyclonal targets ALP
View all literature mentionsThis monoclonal targets Collagen Type I
View all literature mentionsThis polyclonal targets Osteocalcin
View all literature mentionsThis polyclonal targets anti-Perilipin 1 (PLIN1) antibody
View all literature mentionsThis monoclonal targets HA Tag
View all literature mentionsThis polyclonal targets DYKDDDDK tag
View all literature mentionsThis monoclonal targets Beta Actin
View all literature mentionsThis polyclonal targets GFP tag
View all literature mentionsThis unknown targets Human SP7
View all literature mentionsThis polyclonal targets RUNX2
View all literature mentionsThis polyclonal targets beta-Catenin / gamma-Catenin, C-Terminus
View all literature mentionsCell line HEK293T is a Transformed cell line with a species of origin Homo sapiens (Human)
View all literature mentionsThis polyclonal secondary targets IgG (H+L)
View all literature mentionsThis unknown targets IgG (H+L)
View all literature mentionsThis unknown targets Rabbit IgG
View all literature mentionsThis unknown targets Goat Anti-Mouse IgG (H+L) HRP
View all literature mentionsThis polyclonal targets Rabbit Phospho-Beta-Catenin (Ser675) Cy3
View all literature mentionsThis polyclonal targets Histone-H3
View all literature mentionsThis polyclonal targets FABP4
View all literature mentionsThis polyclonal targets CEBPA
View all literature mentionsThis polyclonal targets PPAR Gamma
View all literature mentionsThis monoclonal targets Collagen Type I
View all literature mentionsThis polyclonal targets Osteocalcin
View all literature mentionsThis polyclonal targets ALP
View all literature mentionsThis unknown targets Human SP7
View all literature mentionsThis polyclonal targets RUNX2
View all literature mentionsThis polyclonal targets beta-Catenin / gamma-Catenin, C-Terminus
View all literature mentionsThis polyclonal targets anti-Perilipin 1 (PLIN1) antibody
View all literature mentionsThis monoclonal targets HA Tag
View all literature mentionsThis polyclonal targets DYKDDDDK tag
View all literature mentionsThis monoclonal targets Beta Actin
View all literature mentionsCell line HEK293T is a Transformed cell line with a species of origin Homo sapiens (Human)
View all literature mentionsThis polyclonal targets GFP tag
View all literature mentionsThis polyclonal targets IgG (H+L)
View all literature mentionsThis polyclonal secondary targets IgG (H+L)
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