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Renin-Angiotensin System Antagonism Protects the Diabetic Heart from Ischemia/Reperfusion Injury in Variable Hyperglycemia Duration Settings by a Glucose Transporter Type 4-Mediated Pathway.

Pharmaceuticals (Basel, Switzerland) | 2023

Diabetes mellitus (DM) is a risk factor for cardiovascular diseases, specifically, the ischemic heart diseases (IHD). The renin-angiotensin system (RAS) affects the heart directly and indirectly. However, its role in the protection of the heart against I/R injury is not completely understood. The aim of the current study was to evaluate the efficacy of the angiotensin-converting enzyme (ACE) inhibitor and Angiotensin II receptor (AT1R) blocker or a combination thereof in protection of the heart from I/R injury.

Pubmed ID: 37259385 RIS Download

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Associated grants

  • Agency: Kuwait University,
    Id: YM01/18

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WI (tool)

RRID:RGD_13508588

Rattus norvegicus with name WI from RGD.

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