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Publication

CCNE1 and survival of patients with tubo-ovarian high-grade serous carcinoma: An Ovarian Tumor Tissue Analysis consortium study.

Eun-Young Kang | Ashley Weir | Nicola S Meagher | Kyo Farrington | Gregg S Nelson | Prafull Ghatage | Cheng-Han Lee | Marjorie J Riggan | Adelyn Bolithon | Gordana Popovic | Betty Leung | Katrina Tang | Neil Lambie | Joshua Millstein | Jennifer Alsop | Michael S Anglesio | Beyhan Ataseven | Ellen Barlow | Matthias W Beckmann | Jessica Berger | Christiani Bisinotto | Hans Bösmüller | Jessica Boros | Alison H Brand | Angela Brooks-Wilson | Sara Y Brucker | Michael E Carney | Yovanni Casablanca | Alicia Cazorla-Jiménez | Paul A Cohen | Thomas P Conrads | Linda S Cook | Penny Coulson | Madeleine Courtney-Brooks | Daniel W Cramer | Philip Crowe | Julie M Cunningham | Cezary Cybulski | Kathleen M Darcy | Mona A El-Bahrawy | Esther Elishaev | Ramona Erber | Rhonda Farrell | Sian Fereday | Anna Fischer | María J García | Simon A Gayther | Aleksandra Gentry-Maharaj | C Blake Gilks | AOCS Group | Marcel Grube | Paul R Harnett | Shariska Petersen Harrington | Philipp Harter | Arndt Hartmann | Jonathan L Hecht | Sebastian Heikaus | Alexander Hein | Florian Heitz | Joy Hendley | Brenda Y Hernandez | Susanna Hernando Polo | Sabine Heublein | Akira Hirasawa | Estrid Høgdall | Claus K Høgdall | Hugo M Horlings | David G Huntsman | Tomasz Huzarski | Andrea Jewell | Mercedes Jimenez-Linan | Michael E Jones | Scott H Kaufmann | Catherine J Kennedy | Dineo Khabele | Felix K F Kommoss | Roy F P M Kruitwagen | Diether Lambrechts | Nhu D Le | Marcin Lener | Jenny Lester | Yee Leung | Anna Linder | Liselore Loverix | Jan Lubiński | Rashna Madan | G Larry Maxwell | Francesmary Modugno | Susan L Neuhausen | Alexander Olawaiye | Siel Olbrecht | Sandra Orsulic | José Palacios | Celeste Leigh Pearce | Malcolm C Pike | Carmel M Quinn | Ganendra Raj Mohan | Cristina Rodríguez-Antona | Matthias Ruebner | Andy Ryan | Stuart G Salfinger | Naoko Sasamoto | Joellen M Schildkraut | Minouk J Schoemaker | Mitul Shah | Raghwa Sharma | Yurii B Shvetsov | Naveena Singh | Gabe S Sonke | Linda Steele | Colin J R Stewart | Karin Sundfeldt | Anthony J Swerdlow | Aline Talhouk | Adeline Tan | Sarah E Taylor | Kathryn L Terry | Aleksandra Tołoczko | Nadia Traficante | Koen K Van de Vijver | Maaike A van der Aa | Toon Van Gorp | Els Van Nieuwenhuysen | Lilian van-Wagensveld | Ignace Vergote | Robert A Vierkant | Chen Wang | Lynne R Wilkens | Stacey J Winham | Anna H Wu | Javier Benitez | Andrew Berchuck | Francisco J Candido Dos Reis | Anna DeFazio | Peter A Fasching | Ellen L Goode | Marc T Goodman | Jacek Gronwald | Beth Y Karlan | Stefan Kommoss | Usha Menon | Hans-Peter Sinn | Annette Staebler | James D Brenton | David D Bowtell | Paul D P Pharoah | Susan J Ramus | Martin Köbel
Cancer | 2023

Cyclin E1 (CCNE1) is a potential predictive marker and therapeutic target in tubo-ovarian high-grade serous carcinoma (HGSC). Smaller studies have revealed unfavorable associations for CCNE1 amplification and CCNE1 overexpression with survival, but to date no large-scale, histotype-specific validation has been performed. The hypothesis was that high-level amplification of CCNE1 and CCNE1 overexpression, as well as a combination of the two, are linked to shorter overall survival in HGSC.

Pubmed ID: 36572991 RIS Download

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Associated grants

  • Agency: NCI NIH HHS, United States
    Id: R01CA172404
  • Agency: NCI NIH HHS, United States
    Id: P30 CA008748
  • Agency: Cancer Research UK, United Kingdom
    Id: 15601
  • Agency: NCI NIH HHS, United States
    Id: P30 CA015083
  • Agency: NCI NIH HHS, United States
    Id: R01 CA248288
  • Agency: NCI NIH HHS, United States
    Id: R01 CA243511
  • Agency: NCI NIH HHS, United States
    Id: P30 CA071789
  • Agency: NCI NIH HHS, United States
    Id: P50 CA136393

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