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Publication

Personalized neoantigen vaccine NEO-PV-01 with chemotherapy and anti-PD-1 as first-line treatment for non-squamous non-small cell lung cancer.

Cancer cell | 2022

Neoantigens arising from mutations in tumor DNA provide targets for immune-based therapy. Here, we report the clinical and immune data from a Phase Ib clinical trial of a personalized neoantigen-vaccine NEO-PV-01 in combination with pemetrexed, carboplatin, and pembrolizumab as first-line therapy for advanced non-squamous non-small cell lung cancer (NSCLC). This analysis of 38 patients treated with the regimen demonstrated no treatment-related serious adverse events. Multiple parameters including baseline tumor immune infiltration and on-treatment circulating tumor DNA levels were highly correlated with clinical response. De novo neoantigen-specific CD4+ and CD8+ T cell responses were observed post-vaccination. Epitope spread to non-vaccinating neoantigens, including responses to KRAS G12C and G12V mutations, were detected post-vaccination. Neoantigen-specific CD4+ T cells generated post-vaccination revealed effector and cytotoxic phenotypes with increased CD4+ T cell infiltration in the post-vaccine tumor biopsy. Collectively, these data support the safety and immunogenicity of this regimen in advanced non-squamous NSCLC.

Pubmed ID: 36027916 RIS Download

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Recombinant Anti-CD4 antibody [EPR6855] - BSA and Azide free (antibody)

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CD4 [EPR6855] (antibody)

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TotalSeq(TM)-C0169 anti-human CD366 (Tim-3) (antibody)

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TotalSeq(TM)-C0152 anti-human CD223 (LAG-3) (antibody)

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TotalSeq(TM)-C0390 anti-human CD127 (IL-7Ralpha) (antibody)

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TotalSeq(TM)-C0087 anti-human CD45RO (antibody)

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TotalSeq(TM)-C0063 anti-human CD45RA (antibody)

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TotalSeq(TM)-C0176 anti-human CD39 (antibody)

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TotalSeq(TM)-C0154 anti-human CD27 (antibody)

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TotalSeq(TM)-C0085 anti-human CD25 (antibody)

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TotalSeq(TM)-C0155 anti-human CD107a (LAMP-1) (antibody)

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CD278 (ICOS) (antibody)

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CD278 (ICOS) (antibody)

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CD223 (LAG-3) (antibody)

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CD223 (LAG-3) (antibody)

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CD152 (antibody)

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CD152 (CTLA-4) (antibody)

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CD137 (4-1BB) (antibody)

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CD107a (LAMP-1) (antibody)

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Mouse Anti-Human CD45RA Monoclonal Antibody, Alexa Fluor?? 700 Conjugated, Clone HI100 (antibody)

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APC anti-human CD26 (antibody)

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CD25 (IL-2 Receptor α) (antibody)

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CD19 (antibody)

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CD19 (antibody)

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CD16 (FcγRIII) (antibody)

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CD8 (antibody)

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BUV395 Mouse Anti-Human CD8 (antibody)

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APC-H7 Mouse Anti-Human CD8 Clone SK1 (antibody)

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