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Longitudinal lung function and gas transfer in individuals with idiopathic pulmonary fibrosis: a genome-wide association study.

The Lancet. Respiratory medicine | 2023

Idiopathic pulmonary fibrosis (IPF) is an incurable lung disease characterised by progressive scarring leading to alveolar stiffness, reduced lung capacity, and impeded gas transfer. We aimed to identify genetic variants associated with declining lung capacity or declining gas transfer after diagnosis of IPF.

Pubmed ID: 35985358 RIS Download

Research resources used in this publication

None found

Antibodies used in this publication

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Associated grants

  • Agency: Medical Research Council, United Kingdom
    Id: MC_PC_17228
  • Agency: NHLBI NIH HHS, United States
    Id: R01 HL127349
  • Agency: Wellcome Trust, United Kingdom
    Id: 221680/Z/20/Z
  • Agency: NHLBI NIH HHS, United States
    Id: R01 HL130796
  • Agency: NHLBI NIH HHS, United States
    Id: K23 HL138190
  • Agency: NHLBI NIH HHS, United States
    Id: U01 HL145567
  • Agency: Medical Research Council, United Kingdom
    Id: MC_QA137853
  • Agency: NHLBI NIH HHS, United States
    Id: R01 HL141852
  • Agency: Medical Research Council, United Kingdom
    Id: MC_PC_19004
  • Agency: Medical Research Council, United Kingdom
    Id: MR/V00235X/1
  • Agency: NHLBI NIH HHS, United States
    Id: R21 HL079394
  • Agency: NHLBI NIH HHS, United States
    Id: K23 HL146942
  • Agency: NHLBI NIH HHS, United States
    Id: R56 HL158935
  • Agency: NHLBI NIH HHS, United States
    Id: UH2 HL123886
  • Agency: NHLBI NIH HHS, United States
    Id: UG3 HL145266
  • Agency: Wellcome Trust, United Kingdom
  • Agency: NHLBI NIH HHS, United States
    Id: R21 HL161723

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METAL (tool)

RRID:SCR_002013

Software application designed to facilitate meta-analysis of large datasets (such as several whole genome scans) in a convenient, rapid and memory efficient manner. (entry from Genetic Analysis Software)

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PANTHER (tool)

RRID:SCR_004869

System that classifies genes by their functions, using published scientific experimental evidence and evolutionary relationships to predict function even in absence of direct experimental evidence. Orthologs view is curated orthology relationships between genes for human, mouse, rat, fish, worm, and fly.

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Variant Effect Predictor (tool)

RRID:SCR_007931

Data analysis service to predict the functional consequences of known and unknown variants.

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CoMet (tool)

RRID:SCR_011925

A web-server for fast comparative functional profiling of metagenomes.

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