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Despite the popular use of dietary supplements during conventional cancer treatments, their impacts on the efficacies of prevalent immunotherapies, including immune-checkpoint therapy (ICT), are unknown. Surprisingly, our analyses of electronic health records revealed that ICT-treated patients with cancer who took vitamin E (VitE) had significantly improved survival. In mouse models, VitE increased ICT antitumor efficacy, which depended on dendritic cells (DC). VitE entered DCs via the SCARB1 receptor and restored tumor-associated DC functionality by directly binding to and inhibiting protein tyrosine phosphatase SHP1, a DC-intrinsic checkpoint. SHP1 inhibition, genetically or by VitE treatment, enhanced tumor antigen cross-presentation by DCs and DC-derived extracellular vesicles (DC-EV), triggering systemic antigen-specific T-cell antitumor immunity. Combining VitE with DC-recruiting cancer vaccines or immunogenic chemotherapies greatly boosted ICT efficacy in animals. Therefore, combining VitE supplement or SHP1-inhibited DCs/DC-EVs with DC-enrichment therapies could substantially augment T-cell antitumor immunity and enhance the efficacy of cancer immunotherapies.
Pubmed ID: 35420681 RIS Download
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View all literature mentionsCell line DC2.4 is a Transformed cell line with a species of origin Mus musculus (Mouse)
View all literature mentionsCell line B16-FLT3L is a Cancer cell line with a species of origin Mus musculus (Mouse)
View all literature mentionsCell line B16F10/mGM is a Cancer cell line with a species of origin Mus musculus (Mouse)
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View all literature mentionsMus musculus with name C57BL/6-Tg(TcraTcrb)1100Mjb/J from IMSR.
View all literature mentionsMus musculus with name B6;129S-Scarb1tm1Kri/J from IMSR.
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View all literature mentionsCell line 4T1 is a Cancer cell line with a species of origin Mus musculus (Mouse)
View all literature mentionsCell line B16-F10 is a Cancer cell line with a species of origin Mus musculus (Mouse)
View all literature mentionsMus musculus with name BALB/cJ from IMSR.
View all literature mentionsStatistical analysis software that combines scientific graphing, comprehensive curve fitting (nonlinear regression), understandable statistics, and data organization. Designed for biological research applications in pharmacology, physiology, and other biological fields for data analysis, hypothesis testing, and modeling.
View all literature mentionsHelios, a CyTOF system, comprises the most recent advances in mass cytometry and is designed to provide a new and improved tool for bioanalytical single-cell detection and analysis. This high-performance mass cytometer, from the CyTOF family of instruments, enables the analysis of more than 40 markers and ly allows their quantitative determination with negligible spectral overlap, a result of exquisite resolution between mass detection channels. Helios provides users with 135 detection channels that can simultaneously resolve multiple elemental probes at high acquisition rates, thereby maximizing the per-cell information obtained from a single sample. The expanded mass range of 75 209 amu and superior mass resolution provide researchers with the ability to differentiate adjacent peaks. The Helios system provides fast instrument startup, an easyto-use pneumatic sample loading system, an improved cell detection rate, and enhanced data storage capabilities. These attributes provide researchers with an unparalleled ability to generate high-resolution phenotypic and functional profiles of cells from normal and diseased states.
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View all literature mentionsThis isotype control targets Unknown Specificity
View all literature mentionsThis isotype control targets Trinitrophenol
View all literature mentionsThis monoclonal targets CTLA-4 (CD152)
View all literature mentionsCell line DC2.4 is a Transformed cell line with a species of origin Mus musculus (Mouse)
View all literature mentionsCell line B16-FLT3L is a Cancer cell line with a species of origin Mus musculus (Mouse)
View all literature mentionsCell line B16F10/mGM is a Cancer cell line with a species of origin Mus musculus (Mouse)
View all literature mentionsCell line EO771 is a Cancer cell line with a species of origin Mus musculus (Mouse)
View all literature mentionsCell line EMT6 is a Cancer cell line with a species of origin Mus musculus (Mouse)
View all literature mentionsMus musculus with name C57BL/6-Tg(TcraTcrb)1100Mjb/J from IMSR.
View all literature mentionsMus musculus with name B6;129S-Scarb1tm1Kri/J from IMSR.
View all literature mentionsMus musculus with name C57BL/6J from IMSR.
View all literature mentionsSoftware package for statistics. Used to analyze and visualize data. Extensions can be used, Python and R programming language code, to integrate with open source software. Available for Windows and Mac operating systems.Versions that were produced by SPSS Inc. before the IBM acquisition (Versions 18 and earlier) would be given origin or publisher of SPSS Inc. in Chicago. Versions that were released after the acquisition would be given origin or publisher of IBM Corp. in Armonk, NY.
View all literature mentionsCell line EO771 is a Cancer cell line with a species of origin Mus musculus (Mouse)
View all literature mentionsStatistical analysis software that combines scientific graphing, comprehensive curve fitting (nonlinear regression), understandable statistics, and data organization. Designed for biological research applications in pharmacology, physiology, and other biological fields for data analysis, hypothesis testing, and modeling.
View all literature mentionsHelios, a CyTOF system, comprises the most recent advances in mass cytometry and is designed to provide a new and improved tool for bioanalytical single-cell detection and analysis. This high-performance mass cytometer, from the CyTOF family of instruments, enables the analysis of more than 40 markers and ly allows their quantitative determination with negligible spectral overlap, a result of exquisite resolution between mass detection channels. Helios provides users with 135 detection channels that can simultaneously resolve multiple elemental probes at high acquisition rates, thereby maximizing the per-cell information obtained from a single sample. The expanded mass range of 75 209 amu and superior mass resolution provide researchers with the ability to differentiate adjacent peaks. The Helios system provides fast instrument startup, an easyto-use pneumatic sample loading system, an improved cell detection rate, and enhanced data storage capabilities. These attributes provide researchers with an unparalleled ability to generate high-resolution phenotypic and functional profiles of cells from normal and diseased states.
View all literature mentionsClinScan is Bruker BioSpin's solution for an emerging market of research MRI systems that allows a direct and fast transfer of preclinical studies on animal models to clinical studies on humans. 7 T Bruker USR magnet (Ultra Shielded Refrigerated, bore size 20 cm or 30 cm) n Bruker gradient and shim coil (gradient strength of 290 mT/m or 630 mT/m, slew rate of 1160 T/m/s or 6300 T/m/s) n Bruker RF array coil technology in combination with numerous animal handling accessories n Siemens MAGNETOM Avanto technology with up to 32 receive channels n Clinical routine user interface syngo MR to enable efficient workflow and highly automated state-of-the-art MRI and MRS applications on small animals
View all literature mentionsThis isotype control targets Unknown Specificity
View all literature mentionsThis isotype control targets Trinitrophenol
View all literature mentionsThis monoclonal targets CTLA-4 (CD152)
View all literature mentionsCell line DC2.4 is a Transformed cell line with a species of origin Mus musculus (Mouse)
View all literature mentionsCell line B16F10/mGM is a Cancer cell line with a species of origin Mus musculus (Mouse)
View all literature mentionsCell line 4T1 is a Cancer cell line with a species of origin Mus musculus (Mouse)
View all literature mentionsCell line EMT6 is a Cancer cell line with a species of origin Mus musculus (Mouse)
View all literature mentionsSoftware package for statistics. Used to analyze and visualize data. Extensions can be used, Python and R programming language code, to integrate with open source software. Available for Windows and Mac operating systems.Versions that were produced by SPSS Inc. before the IBM acquisition (Versions 18 and earlier) would be given origin or publisher of SPSS Inc. in Chicago. Versions that were released after the acquisition would be given origin or publisher of IBM Corp. in Armonk, NY.
View all literature mentionsCell line B16-F10 is a Cancer cell line with a species of origin Mus musculus (Mouse)
View all literature mentionsMus musculus with name C57BL/6-Tg(TcraTcrb)1100Mjb/J from IMSR.
View all literature mentionsMus musculus with name B6;129S-Scarb1tm1Kri/J from IMSR.
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