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Combinatorial nanococktails via self-assembling lipid prodrugs for synergistically overcoming drug resistance and effective cancer therapy.

Biomaterials research | 2022

Combinatorial systemic chemotherapy is a powerful treatment paradigm against cancer, but it is fraught with problems due to the emergence of chemoresistance and additive systemic toxicity. In addition, coadministration of individual drugs suffers from uncontrollable pharmacokinetics and biodistribution, resulting in suboptimal combination synergy.

Pubmed ID: 35101154 RIS Download

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Associated grants

  • Agency: Zhejiang Provincial Natural Science Foundation of China,
    Id: LR19H160002
  • Agency: National Natural Science Foundation of China,
    Id: 82073296
  • Agency: National Natural Science Foundation of China,
    Id: 81773193
  • Agency: National Natural Science Foundation of China,
    Id: 81571799

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BALB/cAnNCrl (tool)

RRID:MGI:2683685

laboratory mouse with name BALB/cAnNCrl from MGI.

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NU/J (tool)

RRID:IMSR_JAX:002019

Mus musculus with name NU/J from IMSR.

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