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APOE ε2 resilience for Alzheimer's disease is mediated by plasma lipid species: Analysis of three independent cohort studies.

Alzheimer's & dementia : the journal of the Alzheimer's Association | 2022

The apolipoprotein E (APOE) genotype is the strongest genetic risk factor for late-onset Alzheimer's disease. However, its effect on lipid metabolic pathways, and their mediating effect on disease risk, is poorly understood.

Pubmed ID: 35077012 RIS Download

Research resources used in this publication

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Associated grants

  • Agency: NIA NIH HHS, United States
    Id: R01 AG046171
  • Agency: NIA NIH HHS, United States
    Id: R01 AG019771
  • Agency: NIA NIH HHS, United States
    Id: U01 AG024904
  • Agency: NIA NIH HHS, United States
    Id: U19 AG024904
  • Agency: NCI NIH HHS, United States
    Id: R01 CA129769
  • Agency: NIA NIH HHS, United States
    Id: R01 AG061788
  • Agency: NIA NIH HHS, United States
    Id: RF1 AG059093
  • Agency: NIA NIH HHS, United States
    Id: RF1 AG057452
  • Agency: NIA NIH HHS, United States
    Id: P30 AG010133
  • Agency: NIA NIH HHS, United States
    Id: U24 AG021886
  • Agency: NIA NIH HHS, United States
    Id: R03 AG054936
  • Agency: NIA NIH HHS, United States
    Id: K01 AG049050
  • Agency: NLM NIH HHS, United States
    Id: R01 LM012535
  • Agency: NIA NIH HHS, United States
    Id: U01 AG061359
  • Agency: NIA NIH HHS, United States
    Id: RF1 AG058942
  • Agency: NIA NIH HHS, United States
    Id: RF1 AG051550

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ADNI - Alzheimer's Disease Neuroimaging Initiative (tool)

RRID:SCR_003007

Database of the results of the ADNI study. ADNI is an initiative to develop biomarker-based methods to detect and track the progression of Alzheimer's disease (AD) that provides access to qualified scientists to their database of imaging, clinical, genomic, and biomarker data.

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Foundation for the National Institutes of Health (tool)

RRID:SCR_004493

A public charity whose mission is to support the NIH in its mission to improve health, by forming and facilitating public-private partnerships for biomedical research and training. Its vision is Building Partnerships for Discovery and Innovation to Improve Health. The FNIH draws together the world''s foremost researchers and resources, pressing the frontier to advance critical discoveries. They are recognized as the number-one medical research charity in the countryleveraging support, and convening high level partnerships, for the greatest impact on the most urgent medical challenges we face today. Grants are awarded as part of a public-private partnership with the National Heart, Lung, and Blood Institute (NHLBI) on behalf of The Heart Truth in support of women''s heart health education and research. Funding for the Community Action Program is provided by the FNIH through donations from individuals and corporations including The Heart Truth partners Belk Department Stores, Diet Coke, and Swarovski. Successful biomedical research relies upon the knowledge, training and dedication of those who conduct it. Bringing multiple disciplines to bear on health challenges requires innovation and collaboration on the part of scientists. Foundation for NIH partnerships operate in a variety of ways and formats to recruit, train, empower and retain their next generation of researchers. From lectures and multi-week courses, to scholarships and awards through fellowships and residential training programs, their programs respond to the needs of scientists at every level and stage in their careers.

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