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Acute response to cholinergic challenge predicts long-term response to galantamine treatment in patients with Alzheimer's disease.

British journal of clinical pharmacology | 2022

Cholinesterase inhibitors (CEIs) have been shown to improve cognitive functioning in Alzheimer's disease (AD) patients, but are associated with multiple side effects and only 20-40% of the patients clinically improve. In this study, we aimed to investigate the acute pharmacodynamic (PD) effects of administration of a single dose of galantamine on central nervous system (CNS) functioning in mild to moderate AD patients and its potential to predict long-term treatment response.

Pubmed ID: 34964149 RIS Download

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