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Crosstalk between epithelial sodium channels (ENaC) and basolateral potassium channels (Kir 4.1/Kir 5.1) in the cortical collecting duct.

British journal of pharmacology | 2022

Inwardly rectifying K+ (Kir ) channels located on the basolateral membrane of epithelial cells of the distal nephron play a crucial role in K+ handling and BP control, making these channels an attractive target for the treatment of hypertension. The purpose of the present study was to determine how the inhibition of basolateral Kir 4.1/Kir 5.1 heteromeric K+ channel affects epithelial sodium channel (ENaC)-mediated Na+ transport in the principal cells of cortical collecting duct (CCD).

Pubmed ID: 34904226 RIS Download

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Associated grants

  • Agency: NIDDK NIH HHS, United States
    Id: R01 DK120821
  • Agency: NCRR NIH HHS, United States
    Id: M01 RR000058
  • Agency: BLRD VA, United States
    Id: I01 BX004024
  • Agency: NHLBI NIH HHS, United States
    Id: T32 HL134643
  • Agency: NHLBI NIH HHS, United States
    Id: R35 HL135749
  • Agency: NIDDK NIH HHS, United States
    Id: R01 DK126720
  • Agency: NIDDK NIH HHS, United States
    Id: R56 DK121750

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