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Genetic susceptibility, obesity and lifetime risk of type 2 diabetes: The ARIC study and Rotterdam Study.

Diabetic medicine : a journal of the British Diabetic Association | 2021

Both lifestyle factors and genetic background contribute to the development of type 2 diabetes. Estimation of the lifetime risk of diabetes based on genetic information has not been presented, and the extent to which a normal body weight can offset a high lifetime genetic risk is unknown.

Pubmed ID: 34245042 RIS Download

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Associated grants

  • Agency: NCRR NIH HHS, United States
    Id: UL1 RR025005
  • Agency: NHLBI NIH HHS, United States
    Id: R01 HL086694
  • Agency: NHGRI NIH HHS, United States
    Id: U01 HG004402
  • Agency: NIEHS NIH HHS, United States
    Id: P30 ES030285
  • Agency: NIDDK NIH HHS, United States
    Id: K24 DK106414
  • Agency: NHLBI NIH HHS, United States
    Id: R01 HL087641
  • Agency: NCATS NIH HHS, United States
    Id: UL1 TR003098
  • Agency: NIDDK NIH HHS, United States
    Id: R01 DK089174
  • Agency: NHLBI NIH HHS, United States
    Id: R01 HL059367

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Michigan Imputation Server (tool)

RRID:SCR_017579

Web server to implement whole genotype imputation workflow for efficient parallelization of computationally intensive tasks. Service for imputation that facilitates access to new reference panels and greatly improves user experience and productivity. Used to find haplotype segments and reference panel of sequenced genomes, assign genotypes at untyped markers, improve genome coverage, facilitate comparison and combination of studies that use different marker panels, increase power to detect genetic association, and guide fine mapping.

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