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Magnetic resonance imaging and spectroscopy in late-onset GM2-gangliosidosis.

Molecular genetics and metabolism | 2021

Our study aimed to quantify structural changes in relation to metabolic abnormalities in the cerebellum, thalamus, and parietal cortex of patients with late-onset GM2-gangliosidosis (LOGG), which encompasses late-onset Tay-Sachs disease (LOTS) and Sandhoff disease (LOSD).

Pubmed ID: 34226107 RIS Download

Research resources used in this publication

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Associated grants

  • Agency: NIBIB NIH HHS, United States
    Id: P41 EB015896
  • Agency: NIBIB NIH HHS, United States
    Id: P41 EB030006
  • Agency: NIBIB NIH HHS, United States
    Id: R00 EB016689
  • Agency: NIBIB NIH HHS, United States
    Id: R01 EB027779

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This is a list of tools and resources that we have found mentioned in this publication.


LCModel (tool)

RRID:SCR_014455

Software for automatic quantification of in vivo proton MR spectra. Though it is mainly used for brain analysis, it can be used for a variety of analyses in different areas of the body. It receives time-domain data as input and gives a one page summary output. It is fully automatic, non-interactive, and operator-independent.

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Gannet (tool)

RRID:SCR_016049

Software package designed for the batch analysis of edited magnetic resonance spectroscopy (MRS) data. Gannet runs in Matlab, and is distributed as code rather than executables, empowering users to make local changes. Gannet is designed to run without user intervention, to remove operator variance from the quantification of edited MRS data.

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