Searching across hundreds of databases
Apolipoprotein E ε4 allele (APOE4) is a minor allele of the APOE gene associated with a higher risk for Alzheimer's Disease (AD) and Vascular Dementia (VD). While lipid deposition and chronic inflammation in glia are the commonalities between atherosclerosis, VD, and AD. Hence, we presented an iPSC line of an AD male donor suffering from Cerebrovascular Atherosclerosis with APOE-ε4/ε4 alleles background. Furthermore, we differentiated the iPSCs into astrocyte to explore pathogenesis in APOE4 related dementia. The characterized iPSC line expressed typical pluripotency markers and showed differentiation potential and normal karyotype.
Pubmed ID: 34218115 RIS Download
Publication data is provided by the National Library of Medicine ® and PubMed ®. Data is retrieved from PubMed ® on a weekly schedule. For terms and conditions see the National Library of Medicine Terms and Conditions.
This polyclonal secondary targets IgG (H+L)
View all literature mentionsThis polyclonal secondary targets IgG (H+L)
View all literature mentionsThis unknown targets Rabbit IgG (H+L)
View all literature mentionsThis polyclonal secondary targets IgG (H+L)
View all literature mentionsThis monoclonal targets PAX6
View all literature mentionsThis monoclonal targets Nestin
View all literature mentionsThis monoclonal targets Alpha-Fetoprotein
View all literature mentionsThis monoclonal targets Smooth Muscle Actin
View all literature mentionsThis polyclonal targets EVX1 (N-term)
View all literature mentionsThis monoclonal targets Mouse IgG3 k
View all literature mentionsThis unknown targets TNP
View all literature mentionsThis monoclonal targets Not Applicable
View all literature mentionsThis isotype control targets not applicable
View all literature mentionsThis monoclonal targets TRA-1-60 Antigen
View all literature mentionsThis monoclonal targets Human TRA-1-60 (R)
View all literature mentionsThis monoclonal targets SSEA4 antibody [MC813] - Embryonic Stem Cell Marker
View all literature mentionsThis polyclonal targets Oct4 antibody
View all literature mentionsThis polyclonal targets Nanog
View all literature mentionsThis polyclonal targets sox2
View all literature mentionsThe SciCrunch Infrastructure was developed as a cooperative data platform to be used by diverse communities in making data more FAIR.
scicrunch.org
