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Severe craniofacial and dental abnormalities, typical for patients with progressive Duchenne muscular dystrophy (DMD), are an exellcent demonstration of Melvin L. Moss "functional matrix theory", highlighting the influence of muscle tissue on craniofacial growth and morphology. However, the currently best approved animal model for investigation of this interplay is the mdx-mouse, which offers only a limited time window for research, due to the ability of muscle regeneration, in contrast to the human course of the disease. The aim of this study was to evaluate craniofacial morphology after BTX-A induced muscle paralysis in C57Bl- and mdx-mice, to prove the suitability of BTX-A intervention to inhibit muscle regeneration in mdx-mice and thus, mimicking the human course of the DMD disease.
Pubmed ID: 33675949 RIS Download
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Mus musculus with name C57BL/10ScSnJ from IMSR.
View all literature mentionsMus musculus with name C57BL/10ScSn-Dmdmdx/J from IMSR.
View all literature mentionsMus musculus with name C57BL/10ScSnJ from IMSR.
View all literature mentionsMus musculus with name C57BL/10ScSn-Dmdmdx/J from IMSR.
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