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Cross-Reactivity and Functionality of Approved Human Immune Checkpoint Blockers in Dogs.

Cancers | 2021

Rodent cancer models have limitations in predicting efficacy, tolerability and accompanying biomarkers of ICIs in humans. Companion dogs suffering from neoplastic diseases have gained attention as a highly relevant translational disease model. Despite successful reports of PD-1/PD-L1 blockade in dogs, no compounds are available for veterinary medicine.

Pubmed ID: 33668625 RIS Download

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