Searching across hundreds of databases
Antibodies mediate natural and vaccine-induced immunity against viral and bacterial pathogens, whereas fungi represent a widespread kingdom of pathogenic species for which neither vaccine nor neutralizing antibody therapies are clinically available. Here, using a multi-kingdom antibody profiling (multiKAP) approach, we explore the human antibody repertoires against gut commensal fungi (mycobiota). We identify species preferentially targeted by systemic antibodies in humans, with Candida albicans being the major inducer of antifungal immunoglobulin G (IgG). Fungal colonization of the gut induces germinal center (GC)-dependent B cell expansion in extraintestinal lymphoid tissues and generates systemic antibodies that confer protection against disseminated C. albicans or C. auris infection. Antifungal IgG production depends on the innate immunity regulator CARD9 and CARD9+CX3CR1+ macrophages. In individuals with invasive candidiasis, loss-of-function mutations in CARD9 are associated with impaired antifungal IgG responses. These results reveal an important role of gut commensal fungi in shaping the human antibody repertoire through CARD9-dependent induction of host-protective antifungal IgG.
Pubmed ID: 33548172 RIS Download
Publication data is provided by the National Library of Medicine ® and PubMed ®. Data is retrieved from PubMed ® on a weekly schedule. For terms and conditions see the National Library of Medicine Terms and Conditions.
Portal specializes in visualizing and disseminating single cell data. Allows you to use natural language and faceted search to discover other scientists’ research and share your own findings. Each study includes information on cell types, singular or multiple gene expression, and spatial transcriptomics. Interactive visualizations allow to explore cell clusters and search for related genes.
View all literature mentionsMus musculus with name B6.129P2(Cg)-Cx3cr1tm2.1(cre/ERT2)Litt/WganJ from IMSR.
View all literature mentionsMus musculus with name B6.129-Card9tm1Xlin/J from IMSR.
View all literature mentionsThis unknown targets Human IgG, Fc? Fragment Specific
View all literature mentionsThis unknown targets Mouse IgG, Fc? Fragment Specific
View all literature mentionsThis unknown targets Human Isotype Control
View all literature mentionsThis unknown targets Human Ig
View all literature mentionsThis monoclonal targets CD103 (Integrin alpha E)
View all literature mentionsThis monoclonal targets CD11c
View all literature mentionsThis monoclonal targets CX3CR1
View all literature mentionsThis monoclonal targets CD11b
View all literature mentionsThis monoclonal targets I-A/I-E
View all literature mentionsThis monoclonal targets GL7
View all literature mentionsThis monoclonal targets CD95
View all literature mentionsThis monoclonal targets IgM
View all literature mentionsThis monoclonal targets IgD
View all literature mentionsThis monoclonal targets CD19
View all literature mentionsThis monoclonal targets CD4
View all literature mentionsThis monoclonal targets CD45
View all literature mentionsThis monoclonal targets CD16/CD32
View all literature mentionsThis unknown targets IgG
View all literature mentionsThis unknown targets Goat Isotype Control
View all literature mentionsThis monoclonal targets IgA
View all literature mentionsThis monoclonal targets KLH
View all literature mentionsThis monoclonal targets IgM
View all literature mentionsThis isotype control targets Not Applicable
View all literature mentionsThis unknown targets Mouse IgG, Fc? Fragment Specific
View all literature mentionsThis unknown targets Goat IgG, whole molecule
View all literature mentionsThis monoclonal targets IgG3
View all literature mentionsThis monoclonal secondary targets IgG2b
View all literature mentionsThis monoclonal secondary targets IgG1
View all literature mentionsThis monoclonal targets Rat IgG2a k
View all literature mentionsThis monoclonal targets IgA
View all literature mentionsThis isotype control targets Not Applicable
View all literature mentionsMus musculus with name B6.Cg-Tg(Itgax-cre)1-1Reiz/J from IMSR.
View all literature mentionsMus musculus with name B6.129P2-Tcrbtm1Mom/J from IMSR.
View all literature mentionsMus musculus with name B6.Cg-Rag2tm1.1Cgn/J from IMSR.
View all literature mentionsMus musculus with name B6.129P2-Syktm1.2Tara/J from IMSR.
View all literature mentionsMus musculus with name B6N.129P2-Cx3cr1tm3(Hbegf)Litt/J from IMSR.
View all literature mentionsMus musculus with name B6.129S1-Irf4tm1Rdf/J from IMSR.
View all literature mentionsMus musculus with name B6.129S2-Ighmtm1Cgn/J from IMSR.
View all literature mentionsMus musculus with name C57BL/6J from IMSR.
View all literature mentionsThe SciCrunch Infrastructure was developed as a cooperative data platform to be used by diverse communities in making data more FAIR.
scicrunch.org
