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Characterizing TP53 mutations in ovarian carcinomas with and without concurrent BRCA1 or BRCA2 mutations.

Gynecologic oncology | 2021

Mutations in the TP53 tumor suppressor gene are common in ovarian carcinoma (OC) but their impact on outcomes is controversial. We sought to define the relationship of TP53 mutations to cancer outcomes and their interactions with co-occurrent BRCA1 or BRCA2 (BRCA) mutations, comparing three different TP53 mutation classification schemes.

Pubmed ID: 33375991 RIS Download

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Associated grants

  • Agency: NCI NIH HHS, United States
    Id: P50 CA083636
  • Agency: NCI NIH HHS, United States
    Id: R01 CA099908
  • Agency: NCI NIH HHS, United States
    Id: R01 CA131965
  • Agency: NCI NIH HHS, United States
    Id: R21 CA240885

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ClinVar (tool)

RRID:SCR_006169

Archive of aggregated information about sequence variation and its relationship to human health. Provides reports of relationships among human variations and phenotypes along with supporting evidence. Submissions from clinical testing labs, research labs, locus-specific databases, expert panels and professional societies are welcome. Collects reports of variants found in patient samples, assertions made regarding their clinical significance, information about submitter, and other supporting data. Alleles described in submissions are mapped to reference sequences, and reported according to HGVS standard.

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