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Publication

Functional SARS-CoV-2-Specific Immune Memory Persists after Mild COVID-19.

Cell | 2021

The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) virus is causing a global pandemic, and cases continue to rise. Most infected individuals experience mildly symptomatic coronavirus disease 2019 (COVID-19), but it is unknown whether this can induce persistent immune memory that could contribute to immunity. We performed a longitudinal assessment of individuals recovered from mild COVID-19 to determine whether they develop and sustain multifaceted SARS-CoV-2-specific immunological memory. Recovered individuals developed SARS-CoV-2-specific immunoglobulin (IgG) antibodies, neutralizing plasma, and memory B and memory T cells that persisted for at least 3 months. Our data further reveal that SARS-CoV-2-specific IgG memory B cells increased over time. Additionally, SARS-CoV-2-specific memory lymphocytes exhibited characteristics associated with potent antiviral function: memory T cells secreted cytokines and expanded upon antigen re-encounter, whereas memory B cells expressed receptors capable of neutralizing virus when expressed as monoclonal antibodies. Therefore, mild COVID-19 elicits memory lymphocytes that persist and display functional hallmarks of antiviral immunity.

Pubmed ID: 33296701 RIS Download

Research resources used in this publication

None found

Additional research tools detected in this publication

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Antibodies used in this publication

Associated grants

  • Agency: NIAID NIH HHS, United States
    Id: R01 AI118803
  • Agency: NIAID NIH HHS, United States
    Id: T32 AI106677
  • Agency: NIH HHS, United States
    Id: S10 OD024979
  • Agency: NIDDK NIH HHS, United States
    Id: P30 DK089507
  • Agency: NIAID NIH HHS, United States
    Id: R01 AI127726
  • Agency: NIAID NIH HHS, United States
    Id: R01 AI150178
  • Agency: NCATS NIH HHS, United States
    Id: TL1 TR002318
  • Agency: NIAID NIH HHS, United States
    Id: U01 AI142001
  • Agency: NIAID NIH HHS, United States
    Id: U01 AI151698
  • Agency: NIAID NIH HHS, United States
    Id: U19 AI125378

Publication data is provided by the National Library of Medicine ® and PubMed ®. Data is retrieved from PubMed ® on a weekly schedule. For terms and conditions see the National Library of Medicine Terms and Conditions.

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