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Publication

Developing Human Skin Contains Lymphocytes Demonstrating a Memory Signature.

Cell reports. Medicine | 2020

Lymphocytes in barrier tissues play critical roles in host defense and homeostasis. These cells take up residence in tissues during defined developmental windows, when they may demonstrate distinct phenotypes and functions. Here, we utilized mass and flow cytometry to elucidate early features of human skin immunity. Although most conventional αβ T (Tconv) cells in fetal skin have a naive, proliferative phenotype, a subset of CD4+ Tconv and CD8+ cells demonstrate memory-like features and a propensity for interferon (IFN)γ production. Skin regulatory T cells dynamically accumulate over the second trimester in temporal and regional association with hair follicle development. These fetal skin regulatory T cells (Tregs) demonstrate an effector memory phenotype while differing from their adult counterparts in expression of key effector molecules. Thus, we identify features of prenatal skin lymphocytes that may have key implications for understanding antigen and allergen encounters in utero and in infancy.

Pubmed ID: 33294857 RIS Download

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Antibodies used in this publication

Associated grants

  • Agency: NIAMS NIH HHS, United States
    Id: K08 AR072144
  • Agency: NIAID NIH HHS, United States
    Id: T32 AI007334
  • Agency: NIDDK NIH HHS, United States
    Id: P30 DK063720

Publication data is provided by the National Library of Medicine ® and PubMed ®. Data is retrieved from PubMed ® on a weekly schedule. For terms and conditions see the National Library of Medicine Terms and Conditions.

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