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Interleukin-25-mediated resistance against intestinal trematodes does not depend on the generation of Th2 responses.

Parasites & vectors | 2020

The cytokine interleukin-25 (IL-25) is recognized as the most relevant initiator of protective T helper 2 (Th2) responses in intestinal helminth infections. This cytokine induces resistance against several species of intestinal helminths, including the trematode Echinostoma caproni. E. caproni has been extensively used as an experimental model to study the factors determining resistance to intestinal infections. In the study reported here, we assessed the role of IL-25 in the generation of resistance in mice infected with E. caproni.

Pubmed ID: 33276813 RIS Download

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Associated grants

  • Agency: Wellcome Trust, United Kingdom

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