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Altered synaptic ultrastructure in the prefrontal cortex of Shank3-deficient rats.

Molecular autism | 2020

Deletion or mutations of SHANK3 lead to Phelan-McDermid syndrome and monogenic forms of autism spectrum disorder (ASD). SHANK3 encodes its eponymous scaffolding protein at excitatory glutamatergic synapses. Altered morphology of dendrites and spines in the hippocampus, cerebellum, and striatum have been associated with behavioral impairments in Shank3-deficient animal models. Given the attentional deficit in these animals, our study explored whether deficiency of Shank3 in a rat model alters neuron morphology and synaptic ultrastructure in the medial prefrontal cortex (mPFC).

Pubmed ID: 33203459 RIS Download

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Associated grants

  • Agency: NIMH NIH HHS, United States
    Id: R01 MH101584

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