Searching across hundreds of databases
Recent studies have indicated oligodendroglial-vascular crosstalk during brain development, but the underlying mechanisms are incompletely understood. We report that oligodendrocyte precursor cells (OPCs) contact sprouting endothelial tip cells in mouse, ferret, and human neonatal white matter. Using transgenic mice, we show that increased or decreased OPC density results in cognate changes in white matter vascular investment. Hypoxia induced increases in OPC numbers, vessel density and endothelial cell expression of the Wnt pathway targets Apcdd1 and Axin2 in white matter, suggesting paracrine OPC-endothelial signaling. Conditional knockout of OPC Wntless resulted in diminished white matter vascular growth in normoxia, whereas loss of Wnt7a/b function blunted the angiogenic response to hypoxia, resulting in severe white matter damage. These findings indicate that OPC-endothelial cell interactions regulate neonatal white matter vascular development in a Wnt-dependent manner and further suggest this mechanism is important in attenuating hypoxic injury.
Pubmed ID: 33086038 RIS Download
Publication data is provided by the National Library of Medicine ® and PubMed ®. Data is retrieved from PubMed ® on a weekly schedule. For terms and conditions see the National Library of Medicine Terms and Conditions.
Software package as distribution of ImageJ and ImageJ2 together with Java, Java3D and plugins organized into coherent menu structure. Used to assist research in life sciences.
View all literature mentionsThis polyclonal secondary targets IgG (H+L)
View all literature mentionsThis polyclonal targets IgG (H+L)
View all literature mentionsThis monoclonal targets Neurofilament H NF-H
View all literature mentionsThis polyclonal secondary targets IgY (H+L)
View all literature mentionsThis polyclonal secondary targets IgG (H+L)
View all literature mentionsThis monoclonal targets Olig2
View all literature mentionsThis monoclonal targets Rat Nogo-A MAb (Clone 387521)
View all literature mentionsThis monoclonal targets APC
View all literature mentionsThis monoclonal targets NaBC1 (5)
View all literature mentionsThis unknown targets IgG (H+L)
View all literature mentionsThis polyclonal secondary targets IgG (H+L)
View all literature mentionsThis polyclonal targets GLUT-1 C-terminus
View all literature mentionsThis unknown targets Rabbit IgG (H+L)
View all literature mentionsThis unknown targets Water Channel Aquaporin 4
View all literature mentionsThis polyclonal targets Green Fluorescent Protein (GFP)
View all literature mentionsThis polyclonal targets Mouse IgG (H+L)
View all literature mentionsThis monoclonal targets Claudin 5
View all literature mentionsThis polyclonal targets Iba1
View all literature mentionsThis polyclonal secondary targets IgG (H+L)
View all literature mentionsThis polyclonal targets Collagen Type IV
View all literature mentionsThis unknown targets Polyclonal antibodies are produced by immunizing rabbits with a synthetic peptide (KLH-coupled) corresponding to residues near the carboxy-terminal sequence of human PDGF receptor _
View all literature mentionsThis monoclonal targets TCF-4
View all literature mentionsThis monoclonal targets ERG
View all literature mentionsThis monoclonal targets CD31
View all literature mentionsThis monoclonal targets Alzheimer Precursor Protein A4, aa66-81 of APP
View all literature mentionsThis polyclonal targets Oligodendrocute transcription factor 2
View all literature mentionsThis polyclonal targets NEFH
View all literature mentionsThis polyclonal targets Human Olig2
View all literature mentionsThis polyclonal targets Human CD31, prediluted
View all literature mentionsThis monoclonal targets Ki-67
View all literature mentionsThis monoclonal targets LEF1 (C12A5) Rabbit mAb
View all literature mentionsThis monoclonal targets CD68
View all literature mentionsThis unknown targets Rabbit IgG (H+L)
View all literature mentionsThis polyclonal targets Cleaved Caspase-3 (Asp175)
View all literature mentionsThis monoclonal targets Myelin Basic Protein (MBP), aa 82-87
View all literature mentionsThis monoclonal targets GFAP
View all literature mentionsMus musculus with name B6;129S4-Olig1tm1(cre)Rth/J from IMSR.
View all literature mentionsMus musculus with name STOCK Olig2tm2(TVA.cre)Rth/J from IMSR.
View all literature mentionsMus musculus with name B6;129X1-Wnt7btm2Amc/J from IMSR.
View all literature mentionsMus musculus with name B6;129S1-Wnt7atm1Amc/J from IMSR.
View all literature mentionsMus musculus with name 129S-Wlstm1.1Lan/J from IMSR.
View all literature mentionsMus musculus with name B6.129P2(Cg)-Braftm1Mmcm/J from IMSR.
View all literature mentionsStatistical analysis software that combines scientific graphing, comprehensive curve fitting (nonlinear regression), understandable statistics, and data organization. Designed for biological research applications in pharmacology, physiology, and other biological fields for data analysis, hypothesis testing, and modeling.
View all literature mentionsOpen source Java based image processing software program designed for scientific multidimensional images. ImageJ has been transformed to ImageJ2 application to improve data engine to be sufficient to analyze modern datasets.
View all literature mentionsThe SciCrunch Infrastructure was developed as a cooperative data platform to be used by diverse communities in making data more FAIR.
scicrunch.org
