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SARS-CoV-2 and the safety margins of cell-based biological medicinal products.

Biologicals : journal of the International Association of Biological Standardization | 2020

With the pandemic emergence of SARS-CoV-2, the exposure of cell substrates used for manufacturing of medicines has become a possibility. Cell lines used in biomanufacturing were thus evaluated for their SARS-CoV-2 susceptibility, and the detection of SARS-CoV-2 in culture supernatants by routine adventitious virus testing of fermenter harvest tested.

Pubmed ID: 32891497 RIS Download

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HEK293 (tool)

RRID:CVCL_0045

Cell line HEK293 is a Transformed cell line with a species of origin Homo sapiens (Human)

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Vero (tool)

RRID:CVCL_0059

Cell line Vero is a Spontaneously immortalized cell line with a species of origin Chlorocebus sabaeus

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HT-1080 (tool)

RRID:CVCL_0317

Cell line HT-1080 is a Cancer cell line with a species of origin Homo sapiens (Human)

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MRC-5 (tool)

RRID:CVCL_0440

Cell line MRC-5 is a Finite cell line with a species of origin Homo sapiens

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