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Large-scale discovery of male reproductive tract-specific genes through analysis of RNA-seq datasets.

BMC biology | 2020

The development of a safe, effective, reversible, non-hormonal contraceptive method for men has been an ongoing effort for the past few decades. However, despite significant progress on elucidating the function of key proteins involved in reproduction, understanding male reproductive physiology is limited by incomplete information on the genes expressed in reproductive tissues, and no contraceptive targets have so far reached clinical trials. To advance product development, further identification of novel reproductive tract-specific genes leading to potentially druggable protein targets is imperative.

Pubmed ID: 32814578 RIS Download

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Associated grants

  • Agency: NICHD NIH HHS, United States
    Id: P01 HD087157
  • Agency: NICHD NIH HHS, United States
    Id: R01 HD095341
  • Agency: NIH HHS, United States
    Id: S10 OD023469
  • Agency: Bill and Melinda Gates Foundation, International
    Id: OPP1160866

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B6D2F1/J (tool)

RRID:IMSR_JAX:100006

Mus musculus with name B6D2F1/J from IMSR.

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B6D2F1 (tool)

RRID:MGI:5649818

laboratory mouse with name B6D2F1 from MGI.

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C57BL/6J (tool)

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Mus musculus with name C57BL/6J from IMSR.

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