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Radiosynthesis and evaluation of 18F-labeled dopamine D4-receptor ligands.

Nuclear medicine and biology | 2021

The dopamine D4 receptor (D4R) has attracted considerable attention as potential target for the treatment of a broad range of central nervous system disorders. Although many efforts have been made to improve the performance of putative radioligand candidates, there is still a lack of D4R selective tracers suitable for in vivo PET imaging. Thus, the objective of this work was to develop a D4-selective PET ligand for clinical applications.

Pubmed ID: 32718750 RIS Download

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