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Vecuronium- and Esmolol-Induced Pseudohypernatremia Due to Drug Interference With Ion-Selective Electrodes.

Critical care explorations | 2020

We observed that patients treated with continuous vecuronium or esmolol infusions showed elevated plasma sodium measurements when measured by the routine chemistry analyzer as part of the basic metabolic panel (Vitros 5600; Ortho Clinical Diagnostics, Raritan, NJ), but not by blood gas analyzers (RAPIDLab 1265; Siemens, Tarrytown, NY). Both instruments use direct ion-selective electrode technology, albeit with different sodium ionophores (basic metabolic panel: methyl monensin, blood gas: glass). We questioned if the basic metabolic panel hypernatremia represents artefactual pseudohypernatremia.

Pubmed ID: 32166293 RIS Download

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Associated grants

  • Agency: NIAID NIH HHS, United States
    Id: K08 AI095353
  • Agency: NIDDK NIH HHS, United States
    Id: P50 DK114786
  • Agency: NIDDK NIH HHS, United States
    Id: T32 DK007006

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