Epidemiological studies suggest that metformin may reduce the incidence of cancer in patients with diabetes and multiple late phase clinical trials assessing the potential of repurposing this drug are underway. Transcriptomic profiling of tumour samples is an excellent tool to understand drug bioactivity, identify candidate biomarkers and assess for mechanisms of resistance to therapy.
Pubmed ID: 31819193 RIS Download
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Software that estimates expression at transcript-level resolution and controls for variability evident across replicate libraries.
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