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Publication

Circulating transforming growth factor-β1 facilitates remyelination in the adult central nervous system.

eLife | 2019

Oligodendrocyte maturation is necessary for functional regeneration in the CNS; however, the mechanisms by which the systemic environment regulates oligodendrocyte maturation is unclear. We found that Transforming growth factor (TGF)-β1, which is present in higher levels in the systemic environment, promotes oligodendrocyte maturation. Oligodendrocyte maturation was enhanced by adult mouse serum treatment via TGF-β type I receptor. Decrease in circulating TGF-β1 level prevented remyelination in the spinal cord after toxin-induced demyelination. TGF-β1 administration promoted remyelination and restored neurological function in a multiple sclerosis animal model. Furthermore, TGF-β1 treatment stimulated human oligodendrocyte maturation. These data provide the therapeutic possibility of TGF-β for demyelinating diseases.

Pubmed ID: 31071011 RIS Download

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Associated grants

Agency: Japan Society for the Promotion of Science, International
Id: 16H04672
Agency: The Uehara Memorial Foundation, International
Id: 2017
Agency: Japan Society for the Promotion of Science, International
Id: 17H06178
Agency: Japan Society for the Promotion of Science, International
Id: 19H03554

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