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Purkinje cells play a central role in establishing the cerebellar circuit. Accordingly, disrupting Purkinje cell development impairs cerebellar morphogenesis and motor function. In the Car8wdl mouse model of hereditary ataxia, severe motor deficits arise despite the cerebellum overcoming initial defects in size and morphology.
Pubmed ID: 30867000 RIS Download
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Mus musculus with name B6.Cg-Tg(Npy-MAPT/Sapphire)1Rck/J from IMSR.
View all literature mentionsMus musculus with name C57BLKS/J from IMSR.
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