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Adiposity-Independent Effects of Aging on Insulin Sensitivity and Clearance in Mice and Humans.

Obesity (Silver Spring, Md.) | 2019

Aging is associated with impaired insulin sensitivity and increased prevalence of type 2 diabetes. However, it remains unclear whether aging-associated insulin resistance is due to increased adiposity or other age-related factors. To address this question, the impact of aging on insulin sensitivity was investigated independently of changes in body composition.

Pubmed ID: 30801985 RIS Download

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Associated grants

  • Agency: NHLBI NIH HHS, United States
    Id: R01 HL067974
  • Agency: NHLBI NIH HHS, United States
    Id: R01 HL135622
  • Agency: NCATS NIH HHS, United States
    Id: UL1 TR000124
  • Agency: NHLBI NIH HHS, United States
    Id: P50-HL55005
  • Agency: NIDDK NIH HHS, United States
    Id: P30 DK063491
  • Agency: NIDDK NIH HHS, United States
    Id: U24 DK093000
  • Agency: NIDDK NIH HHS, United States
    Id: P30 DK020593
  • Agency: NCRR NIH HHS, United States
    Id: M01 RR000425
  • Agency: NCRR NIH HHS, United States
    Id: M01 RR000043
  • Agency: NIDDK NIH HHS, United States
    Id: U2C DK093000
  • Agency: NIDDK NIH HHS, United States
    Id: R01 DK079888
  • Agency: NIDDK NIH HHS, United States
    Id: U24 DK059637
  • Agency: NHLBI NIH HHS, United States
    Id: R01 HL088457
  • Agency: NIDDK NIH HHS, United States
    Id: U2C DK059637

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C57BL/6J (tool)

RRID:IMSR_JAX:000664

Mus musculus with name C57BL/6J from IMSR.

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C57BL/6J (tool)

RRID:IMSR_JAX:000664

Mus musculus with name C57BL/6J from IMSR.

View all literature mentions