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Protective versus pathologic pre-exposure cytokine profiles in dengue virus infection.

PLoS neglected tropical diseases | 2018

Hyperendemic circulation of all four types of dengue virus (DENV-1-4) has expanded globally, fueling concern for increased incidence of severe dengue. While the majority of DENV infections are subclinical, epidemiologic studies suggest that type-cross-reactive immunity can influence disease outcome in subsequent infections. The mechanisms controlling these differential clinical outcomes remain poorly defined.

Pubmed ID: 30557313 RIS Download

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Associated grants

  • Agency: NIAID NIH HHS, United States
    Id: P01 AI034533

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FlowJo (tool)

RRID:SCR_008520

Software for single-cell flow cytometry analysis. Its functions include management, display, manipulation, analysis and publication of the data stream produced by flow and mass cytometers.

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BD Biosciences (tool)

RRID:SCR_013311

An Antibody supplier

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Vero (tool)

RRID:CVCL_0059

Cell line Vero is a Spontaneously immortalized cell line with a species of origin Chlorocebus sabaeus

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