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Metformin intervention prevents cardiac dysfunction in a murine model of adult congenital heart disease.

Molecular metabolism | 2019

Congenital heart disease (CHD) is the most frequent birth defect worldwide. The number of adult patients with CHD, now referred to as ACHD, is increasing with improved surgical and treatment interventions. However the mechanisms whereby ACHD predisposes patients to heart dysfunction are still unclear. ACHD is strongly associated with metabolic syndrome, but how ACHD interacts with poor modern lifestyle choices and other comorbidities, such as hypertension, obesity, and diabetes, is mostly unknown.

Pubmed ID: 30482476 RIS Download

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RRID:SCR_015539

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