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We and others have recently reported that the SMC protein Smchd1 is a regulator of chromosome conformation. Smchd1 is critical for the structure of the inactive X chromosome and at autosomal targets such as the Hox genes. However, it is unknown how Smchd1 is recruited to these sites. Here, we report that Smchd1 localizes to the inactive X via the Xist-HnrnpK-PRC1 (polycomb repressive complex 1) pathway. Contrary to previous reports, Smchd1 does not bind Xist or other RNA molecules with any specificity. Rather, the localization of Smchd1 to the inactive X is H2AK119ub dependent. Following perturbation of this interaction, Smchd1 is destabilized, which has consequences for gene silencing genome-wide. Our work adds Smchd1 to the PRC1 silencing pathway for X chromosome inactivation.
Pubmed ID: 30428357 RIS Download
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This polyclonal secondary targets IgG H&L
View all literature mentionsThis polyclonal targets GFP
View all literature mentionsThis polyclonal targets Mouse Light Chain Specific
View all literature mentionsThis monoclonal targets hnRNP-U antibody produced in mouse
View all literature mentionsThis polyclonal targets Histone H3, trimethyl (Lys27)
View all literature mentionsThis monoclonal targets Rabbit Light Chain Specific
View all literature mentionsThis monoclonal targets Histone H2A (Lys119)
View all literature mentionsThis polyclonal secondary targets IgG (H+L)
View all literature mentionsThis monoclonal targets hnRNP K
View all literature mentionsThis polyclonal targets GFP
View all literature mentionsThis monoclonal targets Histone H2A (Lys119)
View all literature mentionsThis monoclonal targets hnRNP-U antibody produced in mouse
View all literature mentionsThis polyclonal targets Mouse Light Chain Specific
View all literature mentionsThis monoclonal targets hnRNP K
View all literature mentionsThis polyclonal secondary targets IgG (H+L)
View all literature mentionsThis polyclonal targets Histone H3, trimethyl (Lys27)
View all literature mentionsThis polyclonal secondary targets IgG H&L
View all literature mentionsThis monoclonal targets Rabbit Light Chain Specific
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