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Can the Ceftriaxone Breakpoints Be Increased Without Compromising Patient Outcomes?

Open forum infectious diseases | 2018

In 2010, the Clinical Laboratory and Standards Institute recommended a 3-fold lowering of ceftriaxone breakpoints to 1 mcg/mL for Enterobacteriaceae. Supportive clinical data at the time were from fewer than 50 patients. We compared the clinical outcomes of adults with Enterobacteriaceae bloodstream infections treated with ceftriaxone compared with matched patients (with exact matching on ceftriaxone minimum inhibitory concentrations [MICs]) treated with extended-spectrum agents to determine if ceftriaxone breakpoints could be increased without negatively impacting patient outcomes.

Pubmed ID: 29992175 RIS Download

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Associated grants

  • Agency: NIAID NIH HHS, United States
    Id: K01 AI103028
  • Agency: NIAID NIH HHS, United States
    Id: K23 AI127935
  • Agency: NIAID NIH HHS, United States
    Id: UM1 AI104681

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