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The neonatal mammal faces an array of sensory stimuli when diverse neuronal types have yet to form sensory maps. How these inputs interact with intrinsic neuronal activity to facilitate circuit assembly is not well understood. By using longitudinal calcium imaging in unanesthetized mouse pups, we show that layer I (LI) interneurons, delineated by co-expression of the 5HT3a serotonin receptor (5HT3aR) and reelin (Re), display spontaneous calcium transients with the highest degree of synchrony among cell types present in the superficial barrel cortex at postnatal day 6 (P6). 5HT3aR Re interneurons are activated by whisker stimulation during this period, and sensory deprivation induces decorrelation of their activity. Moreover, attenuation of thalamic inputs through knockdown of NMDA receptors (NMDARs) in these interneurons results in expansion of whisker responses, aberrant barrel map formation, and deficits in whisker-dependent behavior. These results indicate that recruitment of specific interneuron types during development is critical for adult somatosensory function. VIDEO ABSTRACT.
Pubmed ID: 29937280 RIS Download
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This polyclonal targets SATB2 antibody
View all literature mentionsThis unknown targets 5-HT (Serotonin) Transporter
View all literature mentionsThis polyclonal targets VGluT2
View all literature mentionsThis unknown targets VIP (Vasoactive Intestinal Peptide)
View all literature mentionsThis unknown targets Reelin/CR-50
View all literature mentionsThis polyclonal targets RFP
View all literature mentionsThis unknown targets GFP Antibody
View all literature mentionsMus musculus with name B6.129S4-Grin1tm2Stl/J from IMSR.
View all literature mentionsMus musculus with name B6.Cg-Gt(ROSA)26Sortm32(CAG-COP4*H134R/EYFP)Hze/J from IMSR.
View all literature mentionsMus musculus with name B6;129S6-Gt(ROSA)26Sortm96(CAG-GCaMP6s)Hze/J from IMSR.
View all literature mentionsMus musculus with name B6.129(Cg)-Slc6a4tm1(cre)Xz/J from IMSR.
View all literature mentionsMus musculus with name B6.129S2-Emx1tm1(cre)Krj/J from IMSR.
View all literature mentionsMus musculus with name B6;CBA-Tg(Lhx6-icre)1Kess/J from IMSR.
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