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Methodology, Criteria, and Characterization of Patient-Matched Thyroid Cell Lines and Patient-Derived Tumor Xenografts.

The Journal of clinical endocrinology and metabolism | 2018

To investigate the molecular underpinnings of thyroid cancer, preclinical cell line models are crucial; however, ∼40% of these have been proven to be either duplicates of existing thyroid lines or even nonthyroid-derived lines or are not derived from humans at all. Therefore, we set out to establish procedures and guidelines that should proactively avoid these problems, which facilitated the creation of criteria to make valid preclinical models for thyroid cancer research.

Pubmed ID: 29846633 RIS Download

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Associated grants

  • Agency: NCI NIH HHS, United States
    Id: P30 CA008748
  • Agency: NCI NIH HHS, United States
    Id: P50 CA172012
  • Agency: NCI NIH HHS, United States
    Id: R01 CA136665

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Lamin A + C Antibody (antibody)

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Anti-CD45, clone IBL-5/25 (antibody)

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TPC-1 (cell line)

RRID:CVCL_6298

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RRID:CVCL_QW80

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THJ560 (cell line)

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Cell line BHT-101 is a Cancer cell line with a species of origin Homo sapiens (Human)

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MDA-T85 (cell line)

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Cell line MDA-T85 is a Cancer cell line with a species of origin Homo sapiens (Human)

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T235 (cell line)

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RRID:CVCL_RP38

Cell line LAM136 is a Cancer cell line with a species of origin Homo sapiens (Human)

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RRID:CVCL_A595

Cell line TT2609-B02 is a Cancer cell line with a species of origin Homo sapiens (Human)

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MDA-T120 (cell line)

RRID:CVCL_QW85

Cell line MDA-T120 is a Cancer cell line with a species of origin Homo sapiens (Human)

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TT2609-C02 (cell line)

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Cell line TT2609-C02 is a Cancer cell line with a species of origin Homo sapiens (Human)

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Cell line MDA-T41 is a Cancer cell line with a species of origin Homo sapiens (Human)

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THJ529 (cell line)

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Cell line LUTC-2 is a Cancer cell line with a species of origin Homo sapiens (Human)

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HTh83 (cell line)

RRID:CVCL_0046

Cell line HTh83 is a Cancer cell line with a species of origin Homo sapiens (Human)

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RRID:CVCL_6017

Cell line OCUT-1 is a Cancer cell line with a species of origin Homo sapiens (Human)

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Cell line FRO is a Cancer cell line with a species of origin Homo sapiens (Human)

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8505C (cell line)

RRID:CVCL_1054

Cell line 8505C is a Cancer cell line with a species of origin Homo sapiens (Human)

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HTh104 (cell line)

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SW1736 (cell line)

RRID:CVCL_3883

Cell line SW1736 is a Cancer cell line with a species of origin Homo sapiens (Human)

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T241 (cell line)

RRID:CVCL_M975

Cell line T241 is a Cancer cell line with a species of origin Homo sapiens (Human)

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T243 (cell line)

RRID:CVCL_M976

Cell line T243 is a Cancer cell line with a species of origin Homo sapiens (Human)

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T238 (cell line)

RRID:CVCL_6299

Cell line T238 is a Cancer cell line with a species of origin Homo sapiens (Human)

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ACT-1 [Human thyroid carcinoma] (cell line)

RRID:CVCL_6291

Cell line ACT-1 [Human thyroid carcinoma] is a Cancer cell line with a species of origin Homo sapiens (Human)

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MDA-T68 (cell line)

RRID:CVCL_QW83

Cell line MDA-T68 is a Cancer cell line with a species of origin Homo sapiens (Human)

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LUTC-10 (cell line)

RRID:CVCL_RP46

Cell line LUTC-10 is a Cancer cell line with a species of origin Homo sapiens (Human)

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OGK-M (cell line)

RRID:CVCL_RP35

Cell line OGK-M is a Cancer cell line with a species of origin Homo sapiens (Human)

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KTC-3 (cell line)

RRID:CVCL_W911

Cell line KTC-3 is a Cancer cell line with a species of origin Homo sapiens (Human)

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RRID:CVCL_1219

Cell line FTC-133 is a Cancer cell line with a species of origin Homo sapiens (Human)

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LAM1 (cell line)

RRID:CVCL_W912

Cell line LAM1 is a Cancer cell line with a species of origin Homo sapiens (Human)

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XTC.UC1 (cell line)

RRID:CVCL_9916

Cell line XTC.UC1 is a Cancer cell line with a species of origin Homo sapiens (Human)

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SDAR2 (cell line)

RRID:CVCL_AV64

Cell line SDAR2 is a Cancer cell line with a species of origin Homo sapiens (Human)

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JEM493 (cell line)

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RRID:CVCL_RP47

Cell line LUTC-12 is a Cancer cell line with a species of origin Homo sapiens (Human)

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LUTC-14 (cell line)

RRID:CVCL_RP49

Cell line LUTC-14 is a Cancer cell line with a species of origin Homo sapiens (Human)

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SDAR1 (cell line)

RRID:CVCL_AV63

Cell line SDAR1 is a Cancer cell line with a species of origin Homo sapiens (Human)

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K1 (cell line)

RRID:CVCL_2537

Cell line K1 is a Cancer cell line with a species of origin Homo sapiens (Human)

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FTC-238 (cell line)

RRID:CVCL_2447

Cell line FTC-238 is a Cancer cell line with a species of origin Homo sapiens (Human)

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ML-1 [Human thyroid carcinoma] (cell line)

RRID:CVCL_H525

Cell line ML-1 [Human thyroid carcinoma] is a Cancer cell line with a species of origin Homo sapiens (Human)

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KAT-18 (cell line)

RRID:CVCL_6303

Cell line KAT-18 is a Cancer cell line with a species of origin Homo sapiens (Human)

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CAL-62 (cell line)

RRID:CVCL_1112

Cell line CAL-62 is a Cancer cell line with a species of origin Homo sapiens (Human)

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LUTC-1 (cell line)

RRID:CVCL_RP41

Cell line LUTC-1 is a Cancer cell line with a species of origin Homo sapiens (Human)

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OGK-P (cell line)

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Cell line OGK-P is a Cancer cell line with a species of origin Homo sapiens (Human)

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FF-1 (cell line)

RRID:CVCL_RP34

Cell line FF-1 is a Cancer cell line with a species of origin Homo sapiens (Human)

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FTC-236 (cell line)

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Cell line FTC-236 is a Cancer cell line with a species of origin Homo sapiens (Human)

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THJ-21T (cell line)

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Cell line THJ-21T is a Cancer cell line with a species of origin Homo sapiens (Human)

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THJ-29T (cell line)

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Cell line THJ-29T is a Cancer cell line with a species of origin Homo sapiens (Human)

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KTC-1 (cell line)

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LUTC-8 (cell line)

RRID:CVCL_RP45

Cell line LUTC-8 is a Cancer cell line with a species of origin Homo sapiens (Human)

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C-643 (cell line)

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Cell line C-643 is a Cancer cell line with a species of origin Homo sapiens (Human)

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T351 (cell line)

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Cell line T351 is a Cancer cell line with a species of origin Homo sapiens (Human)

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GLAG-66 (cell line)

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MB-1 (cell line)

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THJ-16T (cell line)

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Cell line THJ-16T is a Cancer cell line with a species of origin Homo sapiens (Human)

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HTh74 (cell line)

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Cell line HTh74 is a Cancer cell line with a species of origin Homo sapiens (Human)

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EAM306 (cell line)

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Cell line EAM306 is a Cancer cell line with a species of origin Homo sapiens (Human)

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KTC-2 (cell line)

RRID:CVCL_6476

Cell line KTC-2 is a Cancer cell line with a species of origin Homo sapiens (Human)

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EAM306 (cell line)

RRID:CVCL_AV62

Cell line EAM306 is a Cancer cell line with a species of origin Homo sapiens (Human)

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MDA-T68 (cell line)

RRID:CVCL_QW83

Cell line MDA-T68 is a Cancer cell line with a species of origin Homo sapiens (Human)

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TPC-1 (cell line)

RRID:CVCL_6298

Cell line TPC-1 is a Cancer cell line with a species of origin Homo sapiens (Human)

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FTC-133 (cell line)

RRID:CVCL_1219

Cell line FTC-133 is a Cancer cell line with a species of origin Homo sapiens (Human)

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LAM136 (cell line)

RRID:CVCL_RP38

Cell line LAM136 is a Cancer cell line with a species of origin Homo sapiens (Human)

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MDA-T22 (cell line)

RRID:CVCL_QW80

Cell line MDA-T22 is a Cancer cell line with a species of origin Homo sapiens (Human)

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LAM1 (cell line)

RRID:CVCL_W912

Cell line LAM1 is a Cancer cell line with a species of origin Homo sapiens (Human)

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MDA-T41 (cell line)

RRID:CVCL_W914

Cell line MDA-T41 is a Cancer cell line with a species of origin Homo sapiens (Human)

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MDA-T120 (cell line)

RRID:CVCL_QW85

Cell line MDA-T120 is a Cancer cell line with a species of origin Homo sapiens (Human)

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GLAG-66 (cell line)

RRID:CVCL_9918

Cell line GLAG-66 is a Cancer cell line with a species of origin Homo sapiens (Human)

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MDA-T32 (cell line)

RRID:CVCL_W913

Cell line MDA-T32 is a Cancer cell line with a species of origin Homo sapiens (Human)

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Lamin A + C Antibody (antibody)

RRID:AB_11034444

This monoclonal targets Lamin A + C

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Anti-CD45, clone IBL-5/25 (antibody)

RRID:AB_10562966

This monoclonal targets CD45 clone IBL-5/25

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K1 (cell line)

RRID:CVCL_2537

Cell line K1 is a Cancer cell line with a species of origin Homo sapiens (Human)

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HTh74 (cell line)

RRID:CVCL_6288

Cell line HTh74 is a Cancer cell line with a species of origin Homo sapiens (Human)

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FF-1 (cell line)

RRID:CVCL_RP34

Cell line FF-1 is a Cancer cell line with a species of origin Homo sapiens (Human)

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HTh104 (cell line)

RRID:CVCL_A427

Cell line HTh104 is a Cancer cell line with a species of origin Homo sapiens (Human)

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CAL-62 (cell line)

RRID:CVCL_1112

Cell line CAL-62 is a Cancer cell line with a species of origin Homo sapiens (Human)

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ACT-1 [Human thyroid carcinoma] (cell line)

RRID:CVCL_6291

Cell line ACT-1 [Human thyroid carcinoma] is a Cancer cell line with a species of origin Homo sapiens (Human)

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C-643 (cell line)

RRID:CVCL_5969

Cell line C-643 is a Cancer cell line with a species of origin Homo sapiens (Human)

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BHT-101 (cell line)

RRID:CVCL_1085

Cell line BHT-101 is a Cancer cell line with a species of origin Homo sapiens (Human)

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THJ529 (cell line)

RRID:CVCL_RP39

Cell line THJ529 is a Cancer cell line with a species of origin Homo sapiens (Human)

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B-CPAP (cell line)

RRID:CVCL_0153

Cell line B-CPAP is a Cancer cell line with a species of origin Homo sapiens (Human)

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THJ-29T (cell line)

RRID:CVCL_W922

Cell line THJ-29T is a Cancer cell line with a species of origin Homo sapiens (Human)

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T243 (cell line)

RRID:CVCL_M976

Cell line T243 is a Cancer cell line with a species of origin Homo sapiens (Human)

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T235 (cell line)

RRID:CVCL_6478

Cell line T235 is a Cancer cell line with a species of origin Homo sapiens (Human)

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XTC.UC1 (cell line)

RRID:CVCL_9916

Cell line XTC.UC1 is a Cancer cell line with a species of origin Homo sapiens (Human)

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8505C (cell line)

RRID:CVCL_1054

Cell line 8505C is a Cancer cell line with a species of origin Homo sapiens (Human)

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KTC-1 (cell line)

RRID:CVCL_6300

Cell line KTC-1 is a Cancer cell line with a species of origin Homo sapiens (Human)

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TT2609-C02 (cell line)

RRID:CVCL_2218

Cell line TT2609-C02 is a Cancer cell line with a species of origin Homo sapiens (Human)

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T351 (cell line)

RRID:CVCL_M977

Cell line T351 is a Cancer cell line with a species of origin Homo sapiens (Human)

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SDAR2 (cell line)

RRID:CVCL_AV64

Cell line SDAR2 is a Cancer cell line with a species of origin Homo sapiens (Human)

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FTC-238 (cell line)

RRID:CVCL_2447

Cell line FTC-238 is a Cancer cell line with a species of origin Homo sapiens (Human)

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SDAR1 (cell line)

RRID:CVCL_AV63

Cell line SDAR1 is a Cancer cell line with a species of origin Homo sapiens (Human)

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FTC-236 (cell line)

RRID:CVCL_2446

Cell line FTC-236 is a Cancer cell line with a species of origin Homo sapiens (Human)

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ML-1 [Human thyroid carcinoma] (cell line)

RRID:CVCL_H525

Cell line ML-1 [Human thyroid carcinoma] is a Cancer cell line with a species of origin Homo sapiens (Human)

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TT2609-B02 (cell line)

RRID:CVCL_A595

Cell line TT2609-B02 is a Cancer cell line with a species of origin Homo sapiens (Human)

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MDA-T85 (cell line)

RRID:CVCL_QW84

Cell line MDA-T85 is a Cancer cell line with a species of origin Homo sapiens (Human)

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THJ560 (cell line)

RRID:CVCL_RP40

Cell line THJ560 is a Cancer cell line with a species of origin Homo sapiens (Human)

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LUTC-8 (cell line)

RRID:CVCL_RP45

Cell line LUTC-8 is a Cancer cell line with a species of origin Homo sapiens (Human)

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LUTC-12 (cell line)

RRID:CVCL_RP47

Cell line LUTC-12 is a Cancer cell line with a species of origin Homo sapiens (Human)

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LUTC-2 (cell line)

RRID:CVCL_RP42

Cell line LUTC-2 is a Cancer cell line with a species of origin Homo sapiens (Human)

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LUTC-10 (cell line)

RRID:CVCL_RP46

Cell line LUTC-10 is a Cancer cell line with a species of origin Homo sapiens (Human)

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MB-1 (cell line)

RRID:CVCL_2109

Cell line MB-1 is a Cancer cell line with a species of origin Homo sapiens

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LUTC-14 (cell line)

RRID:CVCL_RP49

Cell line LUTC-14 is a Cancer cell line with a species of origin Homo sapiens (Human)

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LUTC-1 (cell line)

RRID:CVCL_RP41

Cell line LUTC-1 is a Cancer cell line with a species of origin Homo sapiens (Human)

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JEM493 (cell line)

RRID:CVCL_RP37

Cell line JEM493 is a Cancer cell line with a species of origin Homo sapiens (Human)

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KTC-2 (cell line)

RRID:CVCL_6476

Cell line KTC-2 is a Cancer cell line with a species of origin Homo sapiens (Human)

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HTh112 (cell line)

RRID:CVCL_A428

Cell line HTh112 is a Cancer cell line with a species of origin Homo sapiens (Human)

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KAT-18 (cell line)

RRID:CVCL_6303

Cell line KAT-18 is a Cancer cell line with a species of origin Homo sapiens (Human)

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KTC-3 (cell line)

RRID:CVCL_W911

Cell line KTC-3 is a Cancer cell line with a species of origin Homo sapiens (Human)

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HTh7 (cell line)

RRID:CVCL_6289

Cell line HTh7 is a Cancer cell line with a species of origin Homo sapiens (Human)

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HTh83 (cell line)

RRID:CVCL_0046

Cell line HTh83 is a Cancer cell line with a species of origin Homo sapiens (Human)

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FRO (cell line)

RRID:CVCL_6287

Cell line FRO is a Cancer cell line with a species of origin Homo sapiens (Human)

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TTA-1 (cell line)

RRID:CVCL_6297

Cell line TTA-1 is a Cancer cell line with a species of origin Homo sapiens (Human)

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T238 (cell line)

RRID:CVCL_6299

Cell line T238 is a Cancer cell line with a species of origin Homo sapiens (Human)

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OGK-P (cell line)

RRID:CVCL_RP36

Cell line OGK-P is a Cancer cell line with a species of origin Homo sapiens (Human)

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THJ-16T (cell line)

RRID:CVCL_W920

Cell line THJ-16T is a Cancer cell line with a species of origin Homo sapiens (Human)

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OCUT-1 (cell line)

RRID:CVCL_6017

Cell line OCUT-1 is a Cancer cell line with a species of origin Homo sapiens (Human)

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THJ-21T (cell line)

RRID:CVCL_W921

Cell line THJ-21T is a Cancer cell line with a species of origin Homo sapiens (Human)

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THJ-11T (cell line)

RRID:CVCL_W919

Cell line THJ-11T is a Cancer cell line with a species of origin Homo sapiens (Human)

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T241 (cell line)

RRID:CVCL_M975

Cell line T241 is a Cancer cell line with a species of origin Homo sapiens (Human)

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SW1736 (cell line)

RRID:CVCL_3883

Cell line SW1736 is a Cancer cell line with a species of origin Homo sapiens (Human)

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OGK-M (cell line)

RRID:CVCL_RP35

Cell line OGK-M is a Cancer cell line with a species of origin Homo sapiens (Human)

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