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Over-expression of mitochondrial creatine kinase in the murine heart improves functional recovery and protects against injury following ischaemia-reperfusion.

Cardiovascular research | 2018

Mitochondrial creatine kinase (MtCK) couples ATP production via oxidative phosphorylation to phosphocreatine in the cytosol, which acts as a mobile energy store available for regeneration of ATP at times of high demand. We hypothesized that elevating MtCK would be beneficial in ischaemia-reperfusion (I/R) injury.

Pubmed ID: 29509881 RIS Download

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Associated grants

  • Agency: Wellcome Trust, United Kingdom
    Id: 203141/Z/16/Z
  • Agency: British Heart Foundation, United Kingdom
    Id: FS/11/50/29038
  • Agency: British Heart Foundation, United Kingdom
    Id: RE/08/003
  • Agency: Wellcome Trust, United Kingdom
  • Agency: Wellcome Trust, United Kingdom
    Id: WT 088641/Z/09/Z
  • Agency: British Heart Foundation, United Kingdom
    Id: RE/13/1/30181
  • Agency: British Heart Foundation, United Kingdom
    Id: RG/13/8/30266
  • Agency: Department of Health, United Kingdom

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TopSpin (tool)

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Software package for NMR spectra acquisition, processing, and data analysis. Features include: deconvolution/spectrum simulation/iteration; comprehensive functionalities for processing, displaying and analyzing one and multi-dimensional spectra; and user customization. A full list of features is available on the website.

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C57BL/6J (tool)

RRID:IMSR_JAX:000664

Mus musculus with name C57BL/6J from IMSR.

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