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Publication

Macrophages sensing oxidized DAMPs reprogram their metabolism to support redox homeostasis and inflammation through a TLR2-Syk-ceramide dependent mechanism.

Molecular metabolism | 2018

Macrophages control tissue homeostasis and inflammation by sensing and responding to environmental cues. However, the metabolic adaptation of macrophages to oxidative tissue damage and its translation into inflammatory mechanisms remains enigmatic.

Pubmed ID: 29153923 RIS Download

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Associated grants

Agency: NIDDK NIH HHS, United States
Id: R01 DK096076
Agency: NHLBI NIH HHS, United States
Id: P01 HL120840
Agency: NIDDK NIH HHS, United States
Id: R01 DK101946
Agency: NIDDK NIH HHS, United States
Id: F31 DK108553
Agency: NIGMS NIH HHS, United States
Id: T32 GM007055
Agency: NHLBI NIH HHS, United States
Id: T32 HL007284

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C57BL/6J (tool)

RRID:IMSR_JAX:000664

Mus musculus with name C57BL/6J from IMSR.

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NCTC clone 929 (tool)

RRID:CVCL_0462

Cell line NCTC clone 929 is a Spontaneously immortalized cell line with a species of origin Mus musculus

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B6.129X1-Nfe2l2^tm1Ywk/J (tool)

RRID:IMSR_JAX:017009

Mus musculus with name B6.129X1-Nfe2l2^tm1Ywk/J from IMSR.

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Macrophages sensing oxidized DAMPs reprogram their metabolism to support redox homeostasis and inflammation through a TLR2-Syk-ceramide dependent mechanism.

Research resources used in this publication

Additional research tools detected in this publication

Antibodies used in this publication

Associated grants