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Cathepsin K activity controls cardiotoxin-induced skeletal muscle repair in mice.

Journal of cachexia, sarcopenia and muscle | 2018

Cathepsin K (CatK) is a widely expressed cysteine protease that has gained attention because of its enzymatic and non-enzymatic functions in signalling. Here, we examined whether CatK-deficiency (CatK-/- ) would mitigate injury-related skeletal muscle remodelling and fibrosis in mice, with a special focus on inflammation and muscle cell apoptosis.

Pubmed ID: 29058826 RIS Download

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