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Concomitant hepatocyte apoptosis and regeneration is a hallmark of chronic liver diseases (CLDs) predisposing to hepatocellular carcinoma (HCC). Here, we mechanistically link caspase-8-dependent apoptosis to HCC development via proliferation- and replication-associated DNA damage. Proliferation-associated replication stress, DNA damage, and genetic instability are detectable in CLDs before any neoplastic changes occur. Accumulated levels of hepatocyte apoptosis determine and predict subsequent hepatocarcinogenesis. Proliferation-associated DNA damage is sensed by a complex comprising caspase-8, FADD, c-FLIP, and a kinase-dependent function of RIPK1. This platform requires a non-apoptotic function of caspase-8, but no caspase-3 or caspase-8 cleavage. It may represent a DNA damage-sensing mechanism in hepatocytes that can act via JNK and subsequent phosphorylation of the histone variant H2AX.
Pubmed ID: 28898696 RIS Download
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Commercial antibody vendor which supplies antibodies and other products to life science researchers.
View all literature mentionsCommercial vendor and service provider of laboratory reagents and antibodies. Supplier of scientific instrumentation, reagents and consumables, and software services.
View all literature mentionsSoftware package for interpreting gene expression data. Used for interpretation of a large-scale experiment by identifying pathways and processes.
View all literature mentionsSoftware repository for R packages related to analysis and comprehension of high throughput genomic data. Uses separate set of commands for installation of packages. Software project based on R programming language that provides tools for analysis and comprehension of high throughput genomic data.
View all literature mentionsA portal that provides visualization, analysis and download of large-scale cancer genomics data sets.
View all literature mentionsTHIS RESOURCE IS NO LONGER IN SERVICE. Documented on March 17, 2022. A large-scale database of genetics and genomics data associated to a web-interface and a set of methods and algorithms that can be used for mining the data in it. The database contains two categories of single nucleotide polymorphism (SNP) annotations: # Physical-based annotation where SNPs are categorized according to their position relative to genes (intronic, inter-genic, etc.) and according to linkage disequilibrium (LD) patterns (an inter-genic SNP can be annotated to a gene if it is in LD with variation in the gene). # Functional annotation where SNPs are classified according to their effects on expression levels, i.e. whether they are expression quantitative trait loci (eQTLs) for that gene. SCAN can be utilized in several ways including: (i) queries of the SNP and gene databases; (ii) analysis using the attached tools and algorithms; (iii) downloading files with SNP annotation for various GWA platforms. . eQTL files and reported GWAS from NHGRI may be downloaded.
View all literature mentionsA microarray normalization software (SCAN) to facilitate personalized-medicine workflows with an extension (UPC) that estimates whether a given gene/transcript is active above background levels in a given sample. Rather than processing microarray samples as groups, which can introduce biases and present logistical challenges, SCAN normalizes each sample individually by modeling and removing probe- and array-specific background noise using only data from within each array. SCAN can be applied to one-channel (e.g., Affymetrix) or two-channel (e.g., Agilent) microarrays. The UPC method can be applied to one-channel or two-channel microarrays as well as to RNA-Seq read counts. Because UPC values are represented on the same scale and have an identical interpretation for each platform, they can be used for cross-platform data integration. A
View all literature mentionsAn Organization portal, Antibody supplier, Service resource,
View all literature mentionsSoftware that automatically reads and processes up to 100 raw microarray image files. The software finds and places microarray grids, rejects outlier pixels, accurately determines feature intensities and ratios, flags outlier pixels, and calculates statistical confidences.
View all literature mentionsMus musculus with name B6.Cg-Speer6-ps1Tg(Alb-cre)21Mgn/J from IMSR.
View all literature mentionsCell line U2OS is a Cancer cell line with a species of origin Homo sapiens (Human)
View all literature mentionsCell line Hep-G2 is a Cancer cell line with a species of origin Homo sapiens (Human)
View all literature mentionsAllele Detail: Transgenic, Targeted This is a legacy resource.
View all literature mentionsAllele Detail: Targeted This is a legacy resource.
View all literature mentionsThis monoclonal targets RIP
View all literature mentionsThis polyclonal targets HOIP/RNF31
View all literature mentionsThis polyclonal targets Cleaved Caspase-1 (Asp296)
View all literature mentionsThis monoclonal targets Cleaved Caspase-8 (Asp387)
View all literature mentionsThis monoclonal targets Phospho-p53 (Ser15)
View all literature mentionsThis monoclonal targets RIP3 (phospho S227)
View all literature mentionsThis monoclonal targets ATM antibody produced in mouse
View all literature mentionsThis polyclonal targets Actin N-terminal antibody produced in rabbit
View all literature mentionsThis monoclonal targets BrdU
View all literature mentionsThis polyclonal targets TP53BP1
View all literature mentionsThis polyclonal targets Akt1/2 (N-19)
View all literature mentionsThis polyclonal targets AKT3
View all literature mentionsThis polyclonal targets JUN
View all literature mentionsThis polyclonal targets CASP8
View all literature mentionsThis polyclonal targets SHARPIN
View all literature mentionsThis polyclonal targets gamma H2AX, phospho (Ser139)
View all literature mentionsThis unknown targets gamma H2AX
View all literature mentionsThis polyclonal targets Chk1, phospho (Ser317)
View all literature mentionsThis unknown targets Caspase 8
View all literature mentionsThis monoclonal targets Replication Protein A
View all literature mentionsThis unknown targets Rat IgG (H+L)
View all literature mentionsThis polyclonal targets Mouse Caspase-8
View all literature mentionsThis monoclonal targets c-IAP2
View all literature mentionsThis monoclonal targets p38 MAPK (D13E1) XP Rabbit mAb
View all literature mentionsThis monoclonal targets Mapk14
View all literature mentionsThis monoclonal targets Casp3
View all literature mentionsThis polyclonal targets BRCA1, phospho (Ser1524)
View all literature mentionsThis polyclonal targets ATR, phospho (Ser428)
View all literature mentionsThis polyclonal targets Chk2, phospho (Thr68)
View all literature mentionsThis polyclonal targets Phospho-SAPK/JNK (Thr183/Tyr185)
View all literature mentionsThis monoclonal targets Chk1, phospho (Ser345)
View all literature mentionsThis monoclonal targets ATM protein
View all literature mentionsThis monoclonal targets PCNA
View all literature mentionsThis monoclonal targets GAPDH
View all literature mentionsThis polyclonal targets Caspase-3
View all literature mentionsThis monoclonal targets Histone H2A.X, phospho (Ser139)
View all literature mentionsThis monoclonal targets RIP
View all literature mentionsThis polyclonal targets c-Jun antibody
View all literature mentionsSoftware environment and programming language for statistical computing and graphics. R is integrated suite of software facilities for data manipulation, calculation and graphical display. Can be extended via packages. Some packages are supplied with the R distribution and more are available through CRAN family.It compiles and runs on wide variety of UNIX platforms, Windows and MacOS.
View all literature mentionsA software which acquires and processes data sets, primarily through the Xcalibur system.
View all literature mentionsGenotyping software package that provides DNA sizing and quality allele calls for all Applied Biosystems electrophoresis-based genotyping systems. GeneMapper specializes in multiapplication functionality, including amplified fragment length polymorphism, loss of heterozygosity, microsatellite, and SNP genotyping analysis. The software provides remote auto-analysis and command line operation, and allows for multiuser, client-server deployment.
View all literature mentionsSoftware for single-cell flow cytometry analysis. Its functions include management, display, manipulation, analysis and publication of the data stream produced by flow and mass cytometers.
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Mus musculus with name B6.129S-Tnfrsf1btm1Imx Tnfrsf1a
This monoclonal targets RIP
View all literature mentionsThis monoclonal targets RIP
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