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Protein toxins of the Echis coloratus viper venom directly activate TRPV1.

Biochimica et biophysica acta. General subjects | 2017

Peptide and protein toxins are essential tools to dissect and probe the biology of their target receptors. Venoms target vital physiological processes to evoke pain. Snake venoms contain various factors with the ability to evoke, enhance and sustain pain sensation. While a number of venom-derived toxins were shown to directly target TRPV1 channels expressed on somatosensory nerve terminals to evoke pain response, such toxins were yet to be identified in snake venoms.

Pubmed ID: 28063984 RIS Download

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